Cell Biology Antibodies 14
Anti-FBXW8 Antibody (CAB18122)
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- SKU:
- CAB18122
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FBXW8 Antibody |
| Antibody SKU: | CAB18122 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human FBXW8. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, A-431, Rat lung, Rat heart |
| Immunogen: | Recombinant protein of human FBXW8. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 26259 |
| Uniprot: | Q8N3Y1 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 67kDa |
 | Western blot - FBXW8 Rabbit pAb (CAB18122) |
| Synonyms: | FBW6, FBW8, FBX29, FBXO29, FBXW6, FBXW8 |
| Background: | This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | FBXW8: Substrate-recognition component of a SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Cell development/differentiation Chromosomal Location of Human Ortholog: 12q24.22 Cellular Component: cytoplasm; Golgi apparatus; perinuclear region of cytoplasm Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: cell proliferation; Golgi organization and biogenesis; positive regulation of dendrite morphogenesis; protein ubiquitination |
| NCBI Summary: | This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N3Y1 |
| NCBI GenInfo Identifier: | 296434513 |
| NCBI Gene ID: | 26259 |
| NCBI Accession: | Q8N3Y1.2 |
| UniProt Secondary Accession: | Q8N3Y1,Q9UK95, |
| UniProt Related Accession: | Q8N3Y1 |
| Molecular Weight: | 60,705 Da |
| NCBI Full Name: | F-box/WD repeat-containing protein 8 |
| NCBI Synonym Full Names: | F-box and WD repeat domain containing 8 |
| NCBI Official Symbol: | FBXW8 |
| NCBI Official Synonym Symbols: | FBW6; FBW8; FBX29; FBXW6; FBXO29 |
| NCBI Protein Information: | F-box/WD repeat-containing protein 8 |
| UniProt Protein Name: | F-box/WD repeat-containing protein 8 |
| UniProt Synonym Protein Names: | F-box and WD-40 domain-containing protein 8; F-box only protein 29 |
| Protein Family: | F-box/WD repeat-containing protein |
| UniProt Gene Name: | FBXW8 |
| UniProt Entry Name: | FBXW8_HUMAN |
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