Signal Transduction Antibodies 3

Anti-FBXW5 Antibody (CAB16694)

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SKU:
CAB16694
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-FBXW5 Antibody
Antibody SKU:CAB16694
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human FBXW5.
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human FBXW5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:54461
Uniprot:Q969U6
Cellular Location:Cytoplasm
Calculated MW:42kDa/63kDa
Observed MW:Refer to figures
Synonyms:FBXW5, Fbw5
Background:This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
UniProt Protein Function:FBXW5: Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Belongs to the FBXW5 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm; SCF ubiquitin ligase complex

Molecular Function:protein binding; protein kinase binding

Biological Process: centrosome duplication; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

NCBI Summary:This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
UniProt Code:Q969U6
NCBI GenInfo Identifier:44887886
NCBI Gene ID:54461
NCBI Accession:Q969U6.1
UniProt Secondary Accession:Q969U6,Q59ET5, Q5SPZ8, Q5SPZ9, Q5SQ00, Q5SQ02, Q5SQ03 Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, B2RDZ6,
UniProt Related Accession:Q969U6
Molecular Weight:42,185 Da
NCBI Full Name:F-box/WD repeat-containing protein 5
NCBI Synonym Full Names:F-box and WD repeat domain containing 5
NCBI Official Symbol:FBXW5  
NCBI Official Synonym Symbols:Fbw5  
NCBI Protein Information:F-box/WD repeat-containing protein 5
UniProt Protein Name:F-box/WD repeat-containing protein 5
UniProt Synonym Protein Names:F-box and WD-40 domain-containing protein 5
Protein Family:F-box/WD repeat-containing protein
UniProt Gene Name:FBXW5  
UniProt Entry Name:FBXW5_HUMAN
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