Cell Biology Antibodies 17

Anti-FBXW11 Antibody (CAB20010)

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SKU:
CAB20010
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FBXW11 Antibody
Antibody SKU:CAB20010
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic Peptide of human FBXW11.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, A-431
Immunogen:A synthetic Peptide of human FBXW11.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23291
Uniprot:Q9UKB1
Cellular Location:Cytoplasm, Nucleus
Calculated MW:58kDa/60kDa/62kDa
Observed MW:62kDa
Anti-FBXW11 Antibody (CAB20010)Western blot - FBXW11 Rabbit pAb (CAB20010)
Synonyms:FBXW11, BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
Background:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
UniProt Protein Function:FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; SCF ubiquitin ligase complex; nucleus; cytosol; ubiquitin ligase complex

Molecular Function:protein dimerization activity; protein binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; Wnt receptor signaling pathway; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; positive regulation of circadian rhythm; negative regulation of NF-kappaB import into nucleus; protein amino acid dephosphorylation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UKB1
NCBI GenInfo Identifier:13124267
NCBI Gene ID:23291
NCBI Accession:Q9UKB1.1
UniProt Secondary Accession:Q9UKB1,Q9P2S8, Q9P2S9, Q9Y4C6, B2RC98,
UniProt Related Accession:Q9UKB1
Molecular Weight:60,898 Da
NCBI Full Name:F-box/WD repeat-containing protein 11
NCBI Synonym Full Names:F-box and WD repeat domain containing 11
NCBI Official Symbol:FBXW11  
NCBI Official Synonym Symbols:Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B  
NCBI Protein Information:F-box/WD repeat-containing protein 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 1B; beta-transducin repeat-containing protein 2; homologous to Slimb protein
UniProt Protein Name:F-box/WD repeat-containing protein 11
UniProt Synonym Protein Names:F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS
Protein Family:F-box/WD repeat-containing protein
UniProt Gene Name:FBXW11  
UniProt Entry Name:FBW1B_HUMAN
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