Cell Biology Antibodies 13

Anti-FBXO8 Antibody (CAB17681)

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SKU:
CAB17681
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FBXO8 Antibody
Antibody SKU:CAB17681
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human FBXO8 (NP_036312.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human FBXO8 (NP_036312.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLCK STWG HCSI YNKN PPLG FSFR KLYM QLDE GSLT FNAN PDEG VNYF MSKG ILDD SPKE IAKF IFCT RTLN WKKL RIYL DERR DVLD DLVT LHNF RNQF LPNA LREF FRHI HAPE ERGE YLET LITK FSHR FCAC NPDL M
Gene ID:26269
Uniprot:Q9NRD0
Cellular Location:
Calculated MW:32kDa/37kDa
Observed MW:37kDa
Anti-FBXO8 Antibody (CAB17681)Western blot - FBXO8 Polyclonal Antibody (CAB17681)
Synonyms:DC10, FBS, FBX8, FBXO8
Background:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
UniProt Protein Function:FBXO8: an F-box protein that apparently mediates the ubiquitination of Arf6. May function as a guanine nucleotide exchange factor (GEF) that activates ARF G proteins. The loss of FBXO8 correlates with poor survival in hepatocellular carcinoma.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; GEFs; GEFs, ARF

Chromosomal Location of Human Ortholog: 4q34.1

NCBI Summary:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRD0
NCBI GenInfo Identifier:13124142
NCBI Gene ID:26269
NCBI Accession:Q9NRD0.1
UniProt Secondary Accession:Q9NRD0,Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4, B2RB40, D3DP41 G5E9Z0,
UniProt Related Accession:Q9NRD0
Molecular Weight:32,426 Da
NCBI Full Name:F-box only protein 8
NCBI Synonym Full Names:F-box protein 8
NCBI Official Symbol:FBXO8  
NCBI Official Synonym Symbols:FBS; DC10; FBX8  
NCBI Protein Information:F-box only protein 8
UniProt Protein Name:F-box only protein 8
UniProt Synonym Protein Names:F-box/SEC7 protein FBS
Protein Family:F-box only protein
UniProt Gene Name:FBXO8  
UniProt Entry Name:FBX8_HUMAN
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