Epigenetics & Nuclear Signaling Antibodies 1

Anti-FBXO6 Antibody (CAB10634)

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SKU:
CAB10634
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-FBXO6 Antibody
Antibody SKU:CAB10634
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 104-293 of human FBXO6 (NP_060908.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 104-293 of human FBXO6 (NP_060908.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DFNG GDRW KVES LPGA HGTD FPDP KVKK YFVT SYEM CLKS QLVD LVAE GYWE ELLD TFRP DIVV KDWF AARA DCGC TYQL KVQL ASAD YFVL ASFE PPPV TIQQ WNNA TWTE VSYT FSDY PRGV RYIL FQHG GRDT QYWA GWYG PRVT NSSI VVSP KMTR NQAS SEAQ PGQK HGQE EAAQ SPYR AVVQ IF
Gene ID:26270
Uniprot:Q9NRD1
Cellular Location:Cytoplasm
Calculated MW:33kDa
Observed MW:Refer to figures
Synonyms:FBXO6, FBG2, FBS2, FBX6, Fbx6b
Background:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.
UniProt Protein Function:FBXO6: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex- type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cytoplasm; cytosol; SCF ubiquitin ligase complex

Molecular Function:carbohydrate binding; glycoprotein binding; protein binding; ubiquitin-protein ligase activity

Biological Process: DNA damage checkpoint; DNA repair; ER-associated protein catabolic process; glycoprotein catabolic process; protein polyubiquitination; proteolysis; response to unfolded protein; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

NCBI Summary:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRD1
NCBI GenInfo Identifier:8922188
NCBI Gene ID:26270
NCBI Accession:NP_060908.1
UniProt Secondary Accession:Q9NRD1,Q9UKT3, B1AK42, B2RC88,
UniProt Related Accession:Q9NRD1
Molecular Weight:33,933 Da
NCBI Full Name:F-box only protein 6
NCBI Synonym Full Names:F-box protein 6
NCBI Official Symbol:FBXO6  
NCBI Official Synonym Symbols:FBG2; FBS2; FBX6; Fbx6b  
NCBI Protein Information:F-box only protein 6
UniProt Protein Name:F-box only protein 6
UniProt Synonym Protein Names:F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2
UniProt Gene Name:FBXO6  
UniProt Entry Name:FBX6_HUMAN
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