Cell Biology Antibodies 17

Anti-FBXO5 Antibody (CAB18449)

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SKU:
CAB18449
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FBXO5 Antibody
Antibody SKU:CAB18449
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human FBXO5.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human FBXO5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26271
Uniprot:Q9UKT4
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:EMI1, FBX5, Fbxo31, FBXO5
Background:
UniProt Protein Function:FBX5: a member of the SCFs class of F-box proteins. F-box proteins constitute one of the subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. FBX5 is an early mitotic inhibitor-1 (Emi1) that interacts with Cdc20 and inhibits the anaphase promoting complex (APC/C). APC/C is a ubiquitin ligase that targets mitotic regulatory proteins for degradation. FBX5 accumulates in the S phase and is rapidly degraded in prometaphase.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6q25.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; spindle

Molecular Function:protein binding; protein kinase binding

Biological Process: G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of meiosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of mitosis; regulation of mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle

NCBI Summary:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]
UniProt Code:Q9UKT4
NCBI GenInfo Identifier:24636847
NCBI Gene ID:26271
NCBI Accession:Q9UKT4.1
UniProt Secondary Accession:Q9UKT4,Q5TF47, Q8WV29, Q9UGC8, B3KNX5,
UniProt Related Accession:Q9UKT4
Molecular Weight:45,353 Da
NCBI Full Name:F-box only protein 5
NCBI Synonym Full Names:F-box protein 5
NCBI Official Symbol:FBXO5  
NCBI Official Synonym Symbols:EMI1; FBX5; Fbxo31  
NCBI Protein Information:F-box only protein 5
UniProt Protein Name:F-box only protein 5
UniProt Synonym Protein Names:Early mitotic inhibitor 1
Protein Family:F-box only protein
UniProt Gene Name:FBXO5  
UniProt Entry Name:FBX5_HUMAN
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