Signal Transduction Antibodies 2
Anti-FBXO42 Antibody (CAB14898)
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- SKU:
- CAB14898
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-FBXO42 Antibody |
| Antibody SKU: | CAB14898 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 468-717 of human FBXO42 (NP_061867.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 468-717 of human FBXO42 (NP_061867.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PSAP EGYD LKIG LSLA PRRG SLPD QKDL RLGS IDLN WDLK PASS SNPM DGMD NRTV GGSM RHPP EQTN GVHT PPHV ASAL AGAV SPGA LRRS LEAI KAMS SKGP SASA ALSP PLGS SPGS PGSQ SLSS GETV PIPR PGPA QGDG HSLP PIAR RLGH HPPQ SLNV GKPL YQSM NCKP MQMY VLDI KDTK EKGR VKWK VFNS SSVV GPPE TSLH TVVQ GRGE LIIF GGLM DKKQ NVKY YPKT NALY FVRA KR |
| Gene ID: | 54455 |
| Uniprot: | Q6P3S6 |
| Cellular Location: | |
| Calculated MW: | 77kDa |
| Observed MW: | 78kDa |
| Synonyms: | FBXO42, Fbx42, JFK |
| Background: |
| UniProt Protein Function: | FBXO42: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p36.23-p36.11 |
| NCBI Summary: | Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010] |
| UniProt Code: | Q6P3S6 |
| NCBI GenInfo Identifier: | 21595421 |
| NCBI Gene ID: | 54455 |
| NCBI Accession: | AAH32439.1 |
| UniProt Secondary Accession: | Q6P3S6,Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4 B3KP30, |
| UniProt Related Accession: | Q6P3S6 |
| Molecular Weight: | 77,839 Da |
| NCBI Full Name: | FBXO42 protein, partial |
| NCBI Synonym Full Names: | F-box protein 42 |
| NCBI Official Symbol: | FBXO42 |
| NCBI Official Synonym Symbols: | JFK; Fbx42 |
| NCBI Protein Information: | F-box only protein 42; just one F-box and Kelch domain-containing protein |
| UniProt Protein Name: | F-box only protein 42 |
| UniProt Synonym Protein Names: | Just one F-box and Kelch domain-containing protein |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO42 |
| UniProt Entry Name: | FBX42_HUMAN |
 | Western blot analysis of extracts of mouse lung, using FBXO42 antibody (CAB14898) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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