Signal Transduction Antibodies 1
Anti-FBXO33 Antibody (CAB14303)
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- SKU:
- CAB14303
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-FBXO33 Antibody |
| Antibody SKU: | CAB14303 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-555 of human FBXO33 (NP_976046.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat brain, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-555 of human FBXO33 (NP_976046.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VMHK SLDN MPND EHWK ALSR KSTS FRVY IMAF DIKS EDML KILK PSIP LERI HFDS YITC VSGA IVDL ISRQ YDKF LTHF ILMN DVID TSGF PDLS DNRN EDPL VLLA WRCT KLSL LAIH GYTV WAHN LIAI ARLR GSDL KVLE VTEE SIDF DQGE LADQ DVDP VHNL IEQV SLGL GQPW HAVM DIES LSVF TEPN RHFY REMQ SFSE DI |
| Gene ID: | 254170 |
| Uniprot: | Q7Z6M2 |
| Cellular Location: | |
| Calculated MW: | 62kDa |
| Observed MW: | 63kDa |
| Synonyms: | FBXO33, BMND12, Fbx33, c14_5247 |
| Background: | This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis. |
| UniProt Protein Function: | FBXO33: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q21.1 Molecular Function:protein binding Disease: Bone Mineral Density Quantitative Trait Locus 12 |
| NCBI Summary: | This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q7Z6M2 |
| NCBI GenInfo Identifier: | 51315939 |
| NCBI Gene ID: | 254170 |
| NCBI Accession: | Q7Z6M2.1 |
| UniProt Secondary Accession: | Q7Z6M2,Q6PIR2, Q86TR2, Q86YE0, |
| UniProt Related Accession: | Q7Z6M2 |
| Molecular Weight: | 62,630 Da |
| NCBI Full Name: | F-box only protein 33 |
| NCBI Synonym Full Names: | F-box protein 33 |
| NCBI Official Symbol: | FBXO33 |
| NCBI Official Synonym Symbols: | Fbx33; BMND12; c14_5247 |
| NCBI Protein Information: | F-box only protein 33 |
| UniProt Protein Name: | F-box only protein 33 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO33 |
| UniProt Entry Name: | FBX33_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FBXO33 antibody (CAB14303) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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