Signal Transduction Antibodies 1

Anti-FBXO33 Antibody (CAB14303)

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SKU:
CAB14303
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-FBXO33 Antibody
Antibody SKU:CAB14303
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 346-555 of human FBXO33 (NP_976046.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 346-555 of human FBXO33 (NP_976046.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VMHK SLDN MPND EHWK ALSR KSTS FRVY IMAF DIKS EDML KILK PSIP LERI HFDS YITC VSGA IVDL ISRQ YDKF LTHF ILMN DVID TSGF PDLS DNRN EDPL VLLA WRCT KLSL LAIH GYTV WAHN LIAI ARLR GSDL KVLE VTEE SIDF DQGE LADQ DVDP VHNL IEQV SLGL GQPW HAVM DIES LSVF TEPN RHFY REMQ SFSE DI
Gene ID:254170
Uniprot:Q7Z6M2
Cellular Location:
Calculated MW:62kDa
Observed MW:63kDa
Synonyms:FBXO33, BMND12, Fbx33, c14_5247
Background:This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.
UniProt Protein Function:FBXO33: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 14q21.1

Molecular Function:protein binding

Disease: Bone Mineral Density Quantitative Trait Locus 12

NCBI Summary:This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
UniProt Code:Q7Z6M2
NCBI GenInfo Identifier:51315939
NCBI Gene ID:254170
NCBI Accession:Q7Z6M2.1
UniProt Secondary Accession:Q7Z6M2,Q6PIR2, Q86TR2, Q86YE0,
UniProt Related Accession:Q7Z6M2
Molecular Weight:62,630 Da
NCBI Full Name:F-box only protein 33
NCBI Synonym Full Names:F-box protein 33
NCBI Official Symbol:FBXO33  
NCBI Official Synonym Symbols:Fbx33; BMND12; c14_5247  
NCBI Protein Information:F-box only protein 33
UniProt Protein Name:F-box only protein 33
Protein Family:F-box only protein
UniProt Gene Name:FBXO33  
UniProt Entry Name:FBX33_HUMAN
Anti-FBXO33 Antibody (CAB14303)Western blot analysis of extracts of various cell lines, using FBXO33 antibody (CAB14303) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
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