Signal Transduction Antibodies 2
Anti-FBXO32 Antibody (CAB3193)
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- SKU:
- CAB3193
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-FBXO32 Antibody |
| Antibody SKU: | CAB3193 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-355 of human FBXO32 (NP_478136.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-355 of human FBXO32 (NP_478136.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WQQQ LNNI QITR PAFK GLTF TDLP LCLQ LNIM QRLS DGRD LVSL GQAA PDLH VLSE DRLL WKKL CQYH FSER QIRK RLIL SDKG QLDW KKMY FKLV RCYP RKEQ YGDT LQLC KHCH ILSW KGTD HPCT ANNP ESCS VSLS PQDF INLF KF |
| Gene ID: | 114907 |
| Uniprot: | Q969P5 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 27kDa/42kDa |
| Observed MW: | 40KDa |
| Synonyms: | FBXO32, Fbx32, MAFbx |
| Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: nucleolus; Z disc Molecular Function:protein binding Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q969P5 |
| NCBI GenInfo Identifier: | 20177894 |
| NCBI Gene ID: | 114907 |
| NCBI Accession: | Q969P5.1 |
| UniProt Secondary Accession: | Q969P5,A4KYM0, |
| UniProt Related Accession: | Q969P5 |
| Molecular Weight: | 355 |
| NCBI Full Name: | F-box only protein 32 |
| NCBI Synonym Full Names: | F-box protein 32 |
| NCBI Official Symbol: | FBXO32 |
| NCBI Official Synonym Symbols: | Fbx32; MAFbx |
| NCBI Protein Information: | F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein |
| UniProt Protein Name: | F-box only protein 32 |
| UniProt Synonym Protein Names: | Atrogin-1; Muscle atrophy F-box protein; MAFbx |
| UniProt Gene Name: | FBXO32 |
| UniProt Entry Name: | FBX32_HUMAN |
 | Western blot analysis of extracts of Mouse skeletal muscle, using FBXO32 antibody (CAB3193) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat liver using FBXO32 antibody (CAB3193) at dilution of 1:100 (40x lens). |
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