Signal Transduction Antibodies 3
Anti-FBXO22 Antibody (CAB8367)
- SKU:
- CAB8367
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-FBXO22 Antibody |
Antibody SKU: | CAB8367 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 104-403 of human FBXO22 (NP_671717.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | HeLa, MCF-7 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 104-403 of human FBXO22 (NP_671717.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | YMAD SETF ISLE ECRG HKRA RKRT SMET ALAL EKLF PKQC QVLG IVTP GIVV TPMG SGSN RPQE IEIG ESGF ALLF PQIE GIKI QPFH FIKD PKNL TLER HQLT EVGL LDNP ELRV VLVF GYNC CKVG ASNY LQQV VSTF SDMN IILA GGQV DNLS SLTS EKNP LDID ASGV VGLS FSGH RIQS ATVL LNED VSDE KTAE AAMQ RLKA ANIP EHNT IGFM FACV GRGF QYYR AKGN VEAD AFRK FFPS VPLF GFFG NGEI GCDR IVTG NFIL RKCN EVKD DDLF HSYT TIMA LIHL GSSK |
Gene ID: | 26263 |
Uniprot: | Q8NEZ5 |
Cellular Location: | Cytoplasm, Z line, myofibril, sarcomere |
Calculated MW: | 4kDa/30kDa/44kDa |
Observed MW: | 45kDa |
Synonyms: | FBXO22, FBX22, FISTC1 |
Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | FBXO22: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 15q24.2 Molecular Function:ubiquitin-protein ligase activity Biological Process: protein modification process; ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q8NEZ5 |
NCBI GenInfo Identifier: | 30580428 |
NCBI Gene ID: | 26263 |
NCBI Accession: | Q8NEZ5.1 |
UniProt Secondary Accession: | Q8NEZ5,Q0D2P8, Q6PIL5, Q8IXW3, Q9H824, Q9UKC0, |
UniProt Related Accession: | Q8NEZ5 |
Molecular Weight: | 30,589 Da |
NCBI Full Name: | F-box only protein 22 |
NCBI Synonym Full Names: | F-box protein 22 |
NCBI Official Symbol: | FBXO22 |
NCBI Official Synonym Symbols: | FBX22; FISTC1 |
NCBI Protein Information: | F-box only protein 22 |
UniProt Protein Name: | F-box only protein 22 |
UniProt Synonym Protein Names: | F-box protein FBX22p44 |
Protein Family: | F-box only protein |
UniProt Gene Name: | FBXO22 |
UniProt Entry Name: | FBX22_HUMAN |
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