Signal Transduction Antibodies 3
Anti-FBXO2 Antibody (CAB8579)
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- SKU:
- CAB8579
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-FBXO2 Antibody |
| Antibody SKU: | CAB8579 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-296 of human FBXO2 (NP_036300.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse eye, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-296 of human FBXO2 (NP_036300.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDGD GDPE SVGQ PEEA SPEE QPEE ASAE EERP EDQQ EEEA AAAA AYLD ELPE PLLL RVLA ALPA AELV QACR LVCL RWKE LVDG APLW LLKC QQEG LVPE GGVE EERD HWQQ FYFL SKRR RNLL RNPC GEED LEGW CDVE HGGD GWRV EELP GDSG VEFT HDES VKKY FASS FEWC RKAQ VIDL QAEG YWEE LLDT TQPA IVVK DWYS GRSD AGCL YELT VKLL SEHE NVLA EFSS GQVA VPQD SDGG GWME ISHT FTDY GPGV RFVR FEHG GQDS VYWK GWFG ARVT NSSV WVEP |
| Gene ID: | 26232 |
| Uniprot: | Q9UK22 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Microsome membrane, Peripheral membrane protein |
| Calculated MW: | 33kDa |
| Observed MW: | 39kDa |
| Synonyms: | FBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1 |
| Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. |
| UniProt Protein Function: | FBXO2: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: endoplasmic reticulum; dendritic spine; SCF ubiquitin ligase complex; cytosol Molecular Function:beta-amyloid binding; ubiquitin-protein ligase activity; carbohydrate binding; glycoprotein binding Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; ER-associated protein catabolic process; regulation of protein ubiquitination; protein ubiquitination; protein modification process; glycoprotein catabolic process; proteolysis |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UK22 |
| NCBI GenInfo Identifier: | 15812198 |
| NCBI Gene ID: | 26232 |
| NCBI Accession: | NP_036300.2 |
| UniProt Secondary Accession: | Q9UK22,Q5TGY0, Q6FGJ7, Q8TB29, Q9UKC6, B2R7K7, |
| UniProt Related Accession: | Q9UK22 |
| Molecular Weight: | 60.3 kDa |
| NCBI Full Name: | F-box only protein 2 |
| NCBI Synonym Full Names: | F-box protein 2 |
| NCBI Official Symbol: | FBXO2 |
| NCBI Official Synonym Symbols: | FBG1; FBX2; Fbs1; OCP1; NFB42 |
| NCBI Protein Information: | F-box only protein 2; F-box gene 1; organ of Corti protein 1 |
| UniProt Protein Name: | F-box only protein 2 |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FBXO2 |
| UniProt Entry Name: | FBX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FBXO2 antibody (CAB8579) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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