Cell Biology Antibodies 15

Anti-FBXL14 Antibody (CAB17832)

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SKU:
CAB17832
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FBXL14 Antibody
Antibody SKU:CAB17832
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human FBXL14 (NP_689654.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, HepG2, Mouse thymus, Mouse spleen, Mouse brain, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human FBXL14 (NP_689654.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:METH ISCL FPEL LAMI FGYL DVRD KGRA AQVC TAWR DAAY HKSV WRGV EAKL HLRR ANPS LFPS LQAR GIRR VQIL SLRR SLSY VIQG MANI ESLN LSGC YNLT DNGL GHAF VQEI GSLR ALNL SLCK QITD SSLG RIAQ YLKG LEVL ELGG CSNI TNTG LLLI AWGL QRLK SLNL RSCR HLSD VGIG HLAG MTRS AAEG CLGL EQLT LQDC QKLT DLSL KHIS RGLT GLRL LNLS FCGG ISDA GLLH LSHM GSLR SLNL RSCD NISD TGIM HLAM GSLR LSGL DVSF CDKV GDQS LAYI AQGL DGLK SLSL CSCH ISDD GINR MVRQ MHGL RTLN IGQC VRIT DKGL ELIA EHLS QLTG IDLY GCTR ITKR GLER ITQL PCLK VLNL GLWQ MTDS EKEA RGDF SPLF TVRT RGSS RR
Gene ID:144699
Uniprot:Q8N1E6
Cellular Location:
Calculated MW:45kDa
Observed MW:46kDa
Anti-FBXL14 Antibody (CAB17832)Western blot - FBXL14 Polyclonal Antibody (CAB17832)
Synonyms:Fbl14, FBXL14
Background:Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
UniProt Protein Function:FBXL14: Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm

Molecular Function:protein binding; ubiquitin-protein ligase activity

Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process

NCBI Summary:Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8N1E6
NCBI GenInfo Identifier:48428083
NCBI Gene ID:144699
NCBI Accession:Q8N1E6.1
UniProt Related Accession:Q8N1E6
Molecular Weight:45,886 Da
NCBI Full Name:F-box/LRR-repeat protein 14
NCBI Synonym Full Names:F-box and leucine rich repeat protein 14
NCBI Official Symbol:FBXL14  
NCBI Official Synonym Symbols:Fbl14  
NCBI Protein Information:F-box/LRR-repeat protein 14
UniProt Protein Name:F-box/LRR-repeat protein 14
UniProt Synonym Protein Names:F-box and leucine-rich repeat protein 14
UniProt Gene Name:FBXL14  
UniProt Entry Name:FXL14_HUMAN
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