Signal Transduction Antibodies 1
Anti-FBXL12 Antibody (CAB14589)
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- SKU:
- CAB14589
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-FBXL12 Antibody |
| Antibody SKU: | CAB14589 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | NIH/3T3, SW480, 293T, A-431, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATL VELP DSVL LEIF SYLP VRDR IRIS RVCH RWKR LVDD RWLW RHVD LTLY TMRP KVMW HLLR RYMA SRLH SLRM GGYL FSGS QAPQ LSPA LLRA LGQK CPNL KRLC LHVA DLSM VPIT SLPS TLRT LELH SCEI SMAW LHKQ QDPT VLPL LECI VLDR VPAF RDEH LQGL TRFR ALRS LVLG GTYR VTET GLDA GLQE LSYL QRLE VLGC TLSA DSTL LAIS RHLR DVRK IRLT VRGL SAPG LAVL EGMP ALES LCLQ GPLV TPEM PSPT EILS SCLT MPKL RVLE LQGL GWEG QEAE KILC KGLP HCMV IVRA CPKE SMDW WM |
| Gene ID: | 54850 |
| Uniprot: | Q9NXK8 |
| Cellular Location: | |
| Calculated MW: | 30kDa/37kDa |
| Observed MW: | 37kDa |
| Synonyms: | FBXL12, Fbl12 |
| Background: |
| UniProt Protein Function: | FBXL12: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.2 Molecular Function:protein binding |
| NCBI Summary: | Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NXK8 |
| NCBI GenInfo Identifier: | 38257780 |
| NCBI Gene ID: | 54850 |
| NCBI Accession: | Q9NXK8.1 |
| UniProt Secondary Accession: | Q9NXK8,Q9H5K4, B3KSJ8, |
| UniProt Related Accession: | Q9NXK8 |
| Molecular Weight: | 30,491 Da |
| NCBI Full Name: | F-box/LRR-repeat protein 12 |
| NCBI Synonym Full Names: | F-box and leucine rich repeat protein 12 |
| NCBI Official Symbol: | FBXL12 |
| NCBI Official Synonym Symbols: | Fbl12 |
| NCBI Protein Information: | F-box/LRR-repeat protein 12 |
| UniProt Protein Name: | F-box/LRR-repeat protein 12 |
| UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 12; F-box protein FBL12 |
| UniProt Gene Name: | FBXL12 |
| UniProt Entry Name: | FXL12_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FBXL12 antibody (CAB14589) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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