Signal Transduction Antibodies 3
Anti-Fbx32 Antibody (CAB3699)
(No reviews yet)
Write a Review
- SKU:
- CAB3699
Description
| Antibody Name: | Anti-Fbx32 Antibody |
| Antibody SKU: | CAB3699 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Fbx32 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | A synthesized peptide derived from human Fbx32 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 114907 |
| Uniprot: | Q969P5 |
| Cellular Location: | |
| Calculated MW: | 42kDa |
| Observed MW: | 42KDa |
| Synonyms: | Fbx32, MAFbx |
| Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
| UniProt Protein Function: | FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: nucleolus; Z disc Molecular Function:protein binding Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q969P5 |
| NCBI GenInfo Identifier: | 20177894 |
| NCBI Gene ID: | 114907 |
| NCBI Accession: | Q969P5.1 |
| UniProt Secondary Accession: | Q969P5,A4KYM0, |
| UniProt Related Accession: | Q969P5 |
| Molecular Weight: | 355 |
| NCBI Full Name: | F-box only protein 32 |
| NCBI Synonym Full Names: | F-box protein 32 |
| NCBI Official Symbol: | FBXO32 |
| NCBI Official Synonym Symbols: | Fbx32; MAFbx |
| NCBI Protein Information: | F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein |
| UniProt Protein Name: | F-box only protein 32 |
| UniProt Synonym Protein Names: | Atrogin-1; Muscle atrophy F-box protein; MAFbx |
| UniProt Gene Name: | FBXO32 |
| UniProt Entry Name: | FBX32_HUMAN |
 | Western blot - Fbx32 Rabbit mAb (CAB3699) |
View AllClose
Additional Information
Product Type: |
Antibody |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Research Area: |
Signal Transduction |
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
