Signal Transduction Antibodies 3
Anti-Fbx32 Antibody (CAB3699)
- SKU:
- CAB3699
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-Fbx32 Antibody |
Antibody SKU: | CAB3699 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human Fbx32 |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Mouse, Rat |
Positive Samples: | Mouse skeletal muscle, Rat skeletal muscle |
Immunogen: | A synthesized peptide derived from human Fbx32 |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 114907 |
Uniprot: | Q969P5 |
Cellular Location: | |
Calculated MW: | 42kDa |
Observed MW: | 42KDa |
Synonyms: | Fbx32, MAFbx |
Background: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
UniProt Protein Function: | FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: nucleolus; Z disc Molecular Function:protein binding Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
UniProt Code: | Q969P5 |
NCBI GenInfo Identifier: | 20177894 |
NCBI Gene ID: | 114907 |
NCBI Accession: | Q969P5.1 |
UniProt Secondary Accession: | Q969P5,A4KYM0, |
UniProt Related Accession: | Q969P5 |
Molecular Weight: | 355 |
NCBI Full Name: | F-box only protein 32 |
NCBI Synonym Full Names: | F-box protein 32 |
NCBI Official Symbol: | FBXO32 |
NCBI Official Synonym Symbols: | Fbx32; MAFbx |
NCBI Protein Information: | F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein |
UniProt Protein Name: | F-box only protein 32 |
UniProt Synonym Protein Names: | Atrogin-1; Muscle atrophy F-box protein; MAFbx |
UniProt Gene Name: | FBXO32 |
UniProt Entry Name: | FBX32_HUMAN |
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