Metabolism Antibodies 3
Anti-Fatty Acid Synthase Antibody (CAB19050)
- SKU:
- CAB19050
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-Fatty Acid Synthase Antibody |
| Antibody SKU: | CAB19050 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human FASN |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, HeLa |
| Immunogen: | A synthesized peptide derived from human FASN |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2194 |
| Uniprot: | P49327 |
| Cellular Location: | Cytoplasm, Melanosome |
| Calculated MW: | 273kDa |
| Observed MW: | 273kDa |
 | Western blot - Fatty Acid Synthase Rabbit mAb (CAB19050) |
| Synonyms: | FAS, OA-519, SDR27X1, FASN |
| Background: | The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. |
| UniProt Protein Details: | Protein type:EC 1.3.1.39; EC 1.1.1.100; EC 2.3.1.39; EC 3.1.2.14; Hydrolase; EC 2.3.1.41; EC 4.2.1.59; Oxidoreductase; EC 2.3.1.38; Lyase; EC 2.3.1.85; Lipid Metabolism - fatty acid biosynthesis; Acetyltransferase Chromosomal Location of Human Ortholog: 17q25 Cellular Component: Golgi apparatus; membrane; glycogen granule; mitochondrion; cytoplasm; plasma membrane; melanosome; cytosol Molecular Function:fatty-acid synthase activity; protein homodimerization activity; myristoyl-[acyl-carrier-protein] hydrolase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; drug binding; [acyl-carrier-protein] S-acetyltransferase activity; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; energy reserve metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; fatty acid biosynthetic process; water-soluble vitamin metabolic process |
| NCBI Summary: | The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49327 |
| NCBI GenInfo Identifier: | 269849686 |
| NCBI Gene ID: | 2194 |
| NCBI Accession: | P49327.3 |
| UniProt Secondary Accession: | P49327,Q13479, Q16702, Q4LE83, Q6P4U5, Q6SS02, Q969R1 Q96C68, Q96IT0, |
| UniProt Related Accession: | P49327 |
| Molecular Weight: | 2511 |
| NCBI Full Name: | Fatty acid synthase |
| NCBI Synonym Full Names: | fatty acid synthase |
| NCBI Official Symbol: | FASN |
| NCBI Official Synonym Symbols: | FAS; OA-519; SDR27X1 |
| NCBI Protein Information: | fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1 |
| UniProt Protein Name: | Fatty acid synthase |
| Protein Family: | Fatty acid synthase |
| UniProt Gene Name: | FASN |
| UniProt Entry Name: | FAS_HUMAN |
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