Cell Biology Antibodies 5

Anti-FAT1 Antibody (CAB14681)

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SKU:
CAB14681
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FAT1 Antibody
Antibody SKU:CAB14681
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2700-2900 of human FAT1 (NP_005236.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 2700-2900 of human FAT1 (NP_005236.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPKF SEPF YTFT VSED VPIG TEID LIRA EHSG TVLY SLVK GNTP ESNR DESF VIDR QSGR LKLE KSLD HETT KWYQ FSIL ARCT QDDH EMVA SVDV SIQV KDAN DNSP VFES SPYE AFIV ENLP GGSR VIQI RASD ADSG TNGQ VMYS LDQS QSVE VIES FAIN METG WITT LKEL DHEK RDNY QIKV VASD HGEK IQLS S
Gene ID:2195
Uniprot:Q14517
Cellular Location:Cell membrane, Cytoplasm, Nucleus, Single-pass type I membrane protein, perinuclear region
Calculated MW:506kDa
Observed MW:Refer to figures
Synonyms:FAT1, CDHF7, CDHR8, FAT, ME5, hFat1
Background:This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
UniProt Protein Function:FAT: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: filopodium; focal adhesion; integral to plasma membrane; intercellular junction; lamellipodium; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function:calcium ion binding; protein binding

Biological Process: actin filament organization; anatomical structure morphogenesis; cell adhesion; cell migration; cell-cell adhesion; cell-cell signaling; establishment and/or maintenance of cell polarity; homophilic cell adhesion

NCBI Summary:This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
UniProt Code:Q14517
NCBI GenInfo Identifier:66346693
NCBI Gene ID:2195
NCBI Accession:NP_005236.2
UniProt Related Accession:Q14517
Molecular Weight:506,273 Da
NCBI Full Name:protocadherin Fat 1
NCBI Synonym Full Names:FAT atypical cadherin 1
NCBI Official Symbol:FAT1  
NCBI Official Synonym Symbols:FAT; ME5; CDHF7; CDHR8; hFat1  
NCBI Protein Information:protocadherin Fat 1
UniProt Protein Name:Protocadherin Fat 1
UniProt Synonym Protein Names:Cadherin family member 7; Cadherin-related tumor suppressor homolog; Protein fat homolog
Protein Family:Fatty acid transporter protein
UniProt Gene Name:FAT1  
UniProt Entry Name:FAT1_HUMAN
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