Epigenetics & Nuclear Signaling Antibodies 4

Anti-FANCM Antibody (CAB7602)

(No reviews yet) Write a Review
SKU:
CAB7602
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FANCM Antibody
Antibody SKU:CAB7602
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 390-660 of human FANCM (NP_065988.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 390-660 of human FANCM (NP_065988.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDGT KGMT RSKN ELGR NEDF MKLY NHLE CMFA RTRS TSAN GISA IQQG DKNK KFVY SHPK LKKL EEVV IEHF KSWN AENT TEKK RDET RVMI FSSF RDSV QEIA EMLS QHQP IIRV MTFV GHAS GKST KGFT QKEQ LEVV KQFR DGGY NTLV STCV GEEG LDIG EVDL IICF DSQK SPIR LVQR MGRT GRKR QGRI VIIL SEGR EERI YNQS QSNK RSIY KAIS SNRQ VLHF YQRS PRMV PDGI NPKL HKMF ITHG VYEP EKPS RNLQ RKS
Gene ID:57697
Uniprot:Q8IYD8
Cellular Location:Nucleus
Calculated MW:75kDa/229kDa/232kDa
Observed MW:Refer to figures
Synonyms:FANCM, FAAP250, KIAA1596
Background:The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FANCM: ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Defects in FANCM are a cause of Fanconi anemia complementation group M (FANCM). FANCM is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Belongs to the DEAD box helicase family. DEAH subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.6.4.13; Helicase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: nucleoplasm

Molecular Function:protein binding; nuclease activity; DNA binding; chromatin binding; helicase activity; ATP binding

Biological Process: resolution of meiotic joint molecules as recombinants; DNA repair; replication fork processing

Disease: Tracheoesophageal Fistula With Or Without Esophageal Atresia; Fanconi Anemia, Complementation Group M

NCBI Summary:The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. [provided by RefSeq, Jul 2008]
UniProt Code:Q8IYD8
NCBI GenInfo Identifier:78099254
NCBI Gene ID:57697
NCBI Accession:Q8IYD8.2
UniProt Secondary Accession:Q8IYD8,Q3YFH9, Q8N9X6, Q9HCH6, B2RTQ9,
UniProt Related Accession:Q8IYD8
Molecular Weight:Calculated Molecular Weight: 2048aa; 232kdObserved Molecular Weight: 250kd; 232kd
NCBI Full Name:Fanconi anemia group M protein
NCBI Synonym Full Names:Fanconi anemia, complementation group M
NCBI Official Symbol:FANCM  
NCBI Official Synonym Symbols:FAAP250; KIAA1596  
NCBI Protein Information:Fanconi anemia group M protein; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; protein Hef ortholog
UniProt Protein Name:Fanconi anemia group M protein
UniProt Synonym Protein Names:ATP-dependent RNA helicase FANCM; Fanconi anemia-associated polypeptide of 250 kDa; FAAP250; Protein Hef ortholog
Protein Family:Fanconi anemia group M protein
UniProt Gene Name:FANCM  
UniProt Entry Name:FANCM_HUMAN
Anti-FANCM Antibody (CAB7602)Immunofluorescence analysis of A549 cells using FANCM antibody (CAB7602).
View AllClose

0 Reviews

View AllClose

Related Products