Name: Anti-FANCG Antibody (CAB6206)
Brand: Epigenetics & Nuclear Signaling Antibodies 2
SKU: CAB6206
Availability: OutOfStock

Antibody Name:	Anti-FANCG Antibody
Antibody SKU:	CAB6206
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 343-622 of human FANCG (NP_004620.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	THP-1, U-251MG, HeLa, HepG2, MCF7, Mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 343-622 of human FANCG (NP_004620.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QSQT KHIL ASRC LQTG RAGD AAEH YLDL LALL LDSS EPRF SPPP SPPG PCMP EVFL EAAV ALIQ AGRA QDAL TLCE ELLS RTSS LLPK MSRL WEDA RKGT KELP YCPL WVSA THLL QGQA WVQL GAQK VAIS EFSR CLEL LFRA TPEE KEQG AAFN CEQG CKSD AALQ QLRA AALI SRGL EWVA SGQD TKAL QDFL LSVQ MCPG NRDT YFHL LQTL KRLD RRDE ATAL WWRL EAQT KGSH EDAL WSLP LYLE SYLS WIRP SDRD AFLE EFRT SLPK SCDL
Gene ID:	2189
Uniprot:	O15287
Cellular Location:	Cytoplasm, Nucleus
Calculated MW:	68kDa
Observed MW:	69kDa

Synonyms:

FANCG, FAG, XRCC9

Background:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G.

UniProt Protein Function:	FANCG: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Defects in FANCG are a cause of Fanconi anemia complementation group G (FANCG). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
UniProt Protein Details:	Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 9p13 Cellular Component: cytoplasm; mitochondrion; nucleolus; nucleoplasm; plasma membrane Molecular Function:damaged DNA binding; protein binding Biological Process: cell cycle checkpoint; DNA repair; mitochondrion organization and biogenesis Disease: Fanconi Anemia, Complementation Group G; Tracheoesophageal Fistula With Or Without Esophageal Atresia
NCBI Summary:	The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]
UniProt Code:	O15287
NCBI GenInfo Identifier:	6136453
NCBI Gene ID:	2189
NCBI Accession:	O15287.1
UniProt Related Accession:	O15287
Molecular Weight:	68,554 Da
NCBI Full Name:	Fanconi anemia group G protein
NCBI Synonym Full Names:	Fanconi anemia complementation group G
NCBI Official Symbol:	FANCG
NCBI Official Synonym Symbols:	FAG; XRCC9
NCBI Protein Information:	Fanconi anemia group G protein
UniProt Protein Name:	Fanconi anemia group G protein
UniProt Synonym Protein Names:	DNA repair protein XRCC9
Protein Family:	Fanconi anemia group G protein
UniProt Gene Name:	FANCG
UniProt Entry Name:	FANCG_HUMAN

Western blot analysis of extracts of various cell lines, using FANCG antibody (CAB6206) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 50s.

Antibodies

Anti-Phospho-FANCG-S383 pAb Antibody (CABP0833)

Phospho-FANCG (S383) Antibody (PACO02688)

FANCG Antibody (PACO09229)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)