Cell Biology Antibodies 12

Anti-FAM65B Antibody (CAB9234)

(No reviews yet) Write a Review
SKU:
CAB9234
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FAM65B Antibody
Antibody SKU:CAB9234
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FAM65B (NP_056948.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Mouse thymus, Mouse brain, Rat thymus, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FAM65B (NP_056948.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLVG SQSF SPGG PNGI IRSQ SFAG FSGL QERR SRCN SFIE NSSA LKKP QAKL KKMH NLGH KNNN PPKE PQPK RVEE VYRA LKNG LDEY LEVH QTEL DKLT AQLK DMKR NSRL GVLY DLDK QIKT IERY MRRL EFHI SKVD ELYE AYCI QRRL QDGA SKMK QAFA TSPA SKAA RESL TEIN RSFK EYTE NMCT IEVE LENL LGEF SIKM KG
Gene ID:9750
Uniprot:Q9Y4F9
Cellular Location:Cell projection, Cytoplasm, Mitochondrion, cytoskeleton, filopodium, stereocilium membrane
Calculated MW:65kDa/118kDa
Observed MW:118kDa
Synonyms:RIPOR2, C6orf32, DFNB104, DIFF40, DIFF48, FAM65B, MYONAP, PL48
Background:This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients.
UniProt Protein Function:FAM65B: Isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation. Belongs to the FAM65 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 6p22.3-p21.32

Cellular Component: cytoplasm

Molecular Function:protein binding

Biological Process: sensory perception of sound

Disease: Deafness, Autosomal Recessive 104

NCBI Summary:The protein encoded by this gene stimulates the formation of a non-mitotic multinucleate syncytium from proliferative cytotrophoblasts during trophoblast differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2013]
UniProt Code:Q9Y4F9
NCBI GenInfo Identifier:296439477
NCBI Gene ID:9750
NCBI Accession:Q9Y4F9.4
UniProt Secondary Accession:Q9Y4F9,Q13529, Q5VV37, Q5VV38, Q9BQ28, A6NHP2,
UniProt Related Accession:Q9Y4F9
Molecular Weight:65,692 Da
NCBI Full Name:Protein FAM65B
NCBI Synonym Full Names:family with sequence similarity 65 member B
NCBI Official Symbol:FAM65B  
NCBI Official Synonym Symbols:PL48; DIFF40; DIFF48; MYONAP; C6orf32; DFNB104  
NCBI Protein Information:protein FAM65B
UniProt Protein Name:Protein FAM65B
Protein Family:Protein
UniProt Gene Name:FAM65B  
UniProt Entry Name:FA65B_HUMAN
Anti-FAM65B Polyclonal Antibody (CAB9234)Western blot analysis of extracts of various cell lines, using FAM65B antibody (CAB9234) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products