Cell Death Antibodies 2
Anti-FAIM2 Antibody (CAB6152)
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- SKU:
- CAB6152
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-FAIM2 Antibody |
| Antibody SKU: | CAB6152 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human FAIM2 (NP_036438.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human FAIM2 (NP_036438.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTQG KLSV ANKA PGTE GQQQ VHGE KKEA PAVP SAPP SYEE ATSG EGMK AGAF PPAP TAVP LHPS WAYV DPSS SSSY DNGF PTGD HELF TTFS WDDQ KVRR VFVR K |
| Gene ID: | 23017 |
| Uniprot: | Q9BWQ8 |
| Cellular Location: | Cell junction, Cell membrane, Membrane raft, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 30kDa/35kDa |
| Observed MW: | 35kDa |
| Synonyms: | FAIM2, LFG, LFG2, NGP35, NMP35, TMBIM2 |
| Background: |
| UniProt Protein Function: | FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 12q13 Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft Biological Process: cerebellar granular layer development; apoptosis; regulation of neuron apoptosis; cerebellar Purkinje cell differentiation; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis; negative regulation of apoptosis |
| UniProt Code: | Q9BWQ8 |
| NCBI GenInfo Identifier: | 38503167 |
| NCBI Gene ID: | 23017 |
| NCBI Accession: | Q9BWQ8.1 |
| UniProt Secondary Accession: | Q9BWQ8,Q9UJY9, Q9Y2F7, A8K1W6, B3KR08, |
| UniProt Related Accession: | Q9BWQ8 |
| Molecular Weight: | 316 |
| NCBI Full Name: | Protein lifeguard 2 |
| NCBI Synonym Full Names: | Fas apoptotic inhibitory molecule 2 |
| NCBI Official Symbol: | FAIM2 |
| NCBI Official Synonym Symbols: | LFG; LFG2; NGP35; NMP35; TMBIM2 |
| NCBI Protein Information: | protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2 |
| UniProt Protein Name: | Protein lifeguard 2 |
| UniProt Synonym Protein Names: | Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; Transmembrane BAX inhibitor motif-containing protein 2 |
| Protein Family: | Protein lifeguard |
| UniProt Gene Name: | FAIM2 |
| UniProt Entry Name: | LFG2_HUMAN |
 | Western blot analysis of extracts of mouse brain, using FAIM2 antibody (CAB6152) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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