Signal Transduction Antibodies 1

Anti-FABP7 Antibody (CAB11604)

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SKU:
CAB11604
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-FABP7 Antibody
Antibody SKU:CAB11604
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human FABP7 (NP_001437.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, mouse brain, mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human FABP7 (NP_001437.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVEA FCAT WKLT NSQN FDEY MKAL GVGF ATRQ VGNV TKPT VIIS QEGD KVVI RTLS TFKN TEIS FQLG EEFD ETTA DDRN CKSV VSLD GDKL VHIQ KWDG KETN FVRE IKDG KMVM TLTF GDVV AVRH YEKA
Gene ID:2173
Uniprot:O15540
Cellular Location:Cytoplasm
Calculated MW:14kDa/18kDa
Observed MW:15kDa
Synonyms:FABP7, B-FABP, BLBP, FABPB, MRG
Background:The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes.
UniProt Protein Function:FABP7: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Lipid-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: cell projection; cell soma; cytoplasm; nucleus

Molecular Function:transporter activity; lipid binding

Biological Process: negative regulation of cell proliferation; nervous system development; epithelial cell proliferation; prepulse inhibition; neurogenesis; transport; cell proliferation in forebrain

NCBI Summary:The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
UniProt Code:O15540
NCBI GenInfo Identifier:3122076
NCBI Gene ID:2173
NCBI Accession:O15540.3
UniProt Secondary Accession:O15540,O14951, Q6IAU7, Q9H047, B2R4L1,
UniProt Related Accession:O15540
Molecular Weight:132
NCBI Full Name:Fatty acid-binding protein, brain
NCBI Synonym Full Names:fatty acid binding protein 7, brain
NCBI Official Symbol:FABP7  
NCBI Official Synonym Symbols:MRG; BLBP; FABPB; B-FABP; LTR2-FABP7  
NCBI Protein Information:fatty acid-binding protein, brain; brain lipid binding protein; brain lipid-binding protein; fatty acid-binding protein 7; Hypothetical protein DKFZp547J2313; brain-type fatty acid-binding protein; mammary-derived growth inhibitor related; mammary-derived
UniProt Protein Name:Fatty acid-binding protein, brain
UniProt Synonym Protein Names:Brain lipid-binding protein; BLBP; Brain-type fatty acid-binding protein; B-FABP; Fatty acid-binding protein 7; Mammary-derived growth inhibitor related
UniProt Gene Name:FABP7  
UniProt Entry Name:FABP7_HUMAN
Anti-FABP7 Antibody (CAB11604)Western blot analysis of extracts of various cell lines, using FABP7 antibody (CAB11604) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-FABP7 Antibody (CAB11604)Immunofluorescence analysis of U-251 MG cells using FABP7 antibody (CAB11604) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-FABP7 Antibody (CAB11604)Immunofluorescence analysis of C6 cells using FABP7 antibody (CAB11604) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-FABP7 Antibody (CAB11604)Immunofluorescence analysis of U-251 MG cells using FABP7 antibody (CAB11604) at dilution of 1:100. Blue: DAPI for nuclear staining.
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