Signal Transduction Antibodies 2
Anti-FABP2 Antibody (CAB1621)
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- SKU:
- CAB1621
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-FABP2 Antibody |
| Antibody SKU: | CAB1621 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human FABP2 (NP_000125.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse intestine, Rat intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-132 of human FABP2 (NP_000125.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAFD STWK VDRS ENYD KFME KMGV NIVK RKLA AHDN LKLT ITQE GNKF TVKE SSTF RNIE VVFE LGVT FNYN LADG TELR GTWS LEGN KLIG KFKR TDNG NELN TVRE IIGD ELVQ TYVY EGVE AKRI FKKD |
| Gene ID: | 2169 |
| Uniprot: | P12104 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 15kDa |
| Observed MW: | 15kDa |
| Synonyms: | FABP2, FABPI, I-FABP |
| Background: | The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. |
| UniProt Protein Function: | FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q28-q31 Cellular Component: cytoplasm Molecular Function:transporter activity; fatty acid binding Biological Process: transport; digestion |
| NCBI Summary: | The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12104 |
| NCBI GenInfo Identifier: | 119805 |
| NCBI Gene ID: | 2169 |
| NCBI Accession: | P12104.2 |
| UniProt Secondary Accession: | P12104,Q2NKJ1, |
| UniProt Related Accession: | P12104 |
| Molecular Weight: | 132 |
| NCBI Full Name: | Fatty acid-binding protein, intestinal |
| NCBI Synonym Full Names: | fatty acid binding protein 2, intestinal |
| NCBI Official Symbol: | FABP2 |
| NCBI Official Synonym Symbols: | FABPI; I-FABP |
| NCBI Protein Information: | fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein |
| UniProt Protein Name: | Fatty acid-binding protein, intestinal |
| UniProt Synonym Protein Names: | Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP |
| Protein Family: | Fatty acid-binding protein |
| UniProt Gene Name: | FABP2 |
| UniProt Entry Name: | FABPI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FABP2 antibody (CAB1621) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of HeLa cells using FABP2 antibody (CAB1621). Blue: DAPI for nuclear staining. |
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