Cell Biology Antibodies 17

Anti-Ezrin Antibody (CAB19048)

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SKU:
CAB19048

Description

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Antibody Name:Anti-Ezrin Antibody
Antibody SKU:CAB19048
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Ezrin
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HCT116
Immunogen:A synthesized peptide derived from human Ezrin
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7430
Uniprot:P15311
Cellular Location:
Calculated MW:80kDa
Observed MW:80kDa
Anti-Ezrin Antibody (CAB19048)Western blot - Ezrin Rabbit mAb (CAB19048)
Synonyms:CVIL, CVL, HEL-S-105, VIL2, EZR, Ezrin, ezrin
Background:The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Function:Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: cortical cytoskeleton; extracellular space; microvillus; focal adhesion; basolateral plasma membrane; T-tubule; actin filament; cytosol; lipid raft; actin cytoskeleton; ruffle; extrinsic to membrane; membrane; apical part of cell; microvillus membrane; apical plasma membrane; nucleolus; plasma membrane; uropod; vesicle; filopodium

Molecular Function:actin filament binding; protein domain specific binding; protein binding; cell adhesion molecule binding

Biological Process: actin filament bundle formation; axon guidance; microvillus biogenesis; regulation of cell shape; leukocyte adhesion; filopodium formation; cytoskeletal anchoring; receptor internalization; membrane to membrane docking; establishment of epithelial cell polarity

NCBI Summary:The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P15311
NCBI GenInfo Identifier:125987826
NCBI Gene ID:7430
NCBI Accession:P15311.4
UniProt Secondary Accession:P15311,P23714, Q4VX75, Q96CU8, Q9NSJ4, E1P5A8,
UniProt Related Accession:P15311
Molecular Weight:586
NCBI Full Name:Ezrin
NCBI Synonym Full Names:ezrin
NCBI Official Symbol:EZR  
NCBI Official Synonym Symbols:CVL; CVIL; VIL2; HEL-S-105  
NCBI Protein Information:ezrin; p81; villin-2; cytovillin 2; villin 2 (ezrin); epididymis secretory protein Li 105
UniProt Protein Name:Ezrin
UniProt Synonym Protein Names:Cytovillin; Villin-2; p81
Protein Family:Ezrin
UniProt Gene Name:EZR  
UniProt Entry Name:EZRI_HUMAN
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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