Cell Biology Antibodies 6

Anti-EXTL2 Antibody (CAB15669)

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SKU:
CAB15669
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EXTL2 Antibody
Antibody SKU:CAB15669
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 41-330 of human EXTL2 (NP_001430.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 41-330 of human EXTL2 (NP_001430.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PSVK EDKM LMLR REIK SQGK STMD SFTL IMQT YNRT DLLL KLLN HYQA VPNL HKVI VVWN NIGE KAPD ELWN SLGP HPIP VIFK QQTA NRMR NRLQ VFPE LETN AVLM VDDD TLIS TPDL VFAF SVWQ QFPD QIVG FVPR KHVS TSSG IYSY GSFE MQAP GSGN GDQY SMVL IGAS FFNS KYLE LFQR QPAA VHAL IDDT QNCD DIAM NFII AKHI GKTS GIFV KPVN MDNL EKET NSGY SGMW HRAE HALQ RSYC INKL VNIY DSMP LRYS NIMI SQFG FPYA NYKR KI
Gene ID:2135
Uniprot:Q9UBQ6
Cellular Location:Endoplasmic reticulum membrane, Secreted, Single-pass type II membrane protein
Calculated MW:37kDa
Observed MW:37kDa
Synonyms:EXTL2, EXTR2
Background:
UniProt Protein Function:EXTL2: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Belongs to the glycosyltransferase 47 family.
UniProt Protein Details:

Protein type:Transferase; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.223; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: endoplasmic reticulum

Molecular Function:alpha-1,4-N-acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Biological Process: N-acetylglucosamine metabolic process; UDP-N-acetylgalactosamine metabolic process

UniProt Code:Q9UBQ6
NCBI GenInfo Identifier:9296986
NCBI Gene ID:2135
NCBI Accession:Q9UBQ6.1
UniProt Secondary Accession:Q9UBQ6,B2R795, D3DT60,
UniProt Related Accession:Q9UBQ6
Molecular Weight:37,466 Da
NCBI Full Name:Exostosin-like 2
NCBI Synonym Full Names:exostosin like glycosyltransferase 2
NCBI Official Symbol:EXTL2  
NCBI Official Synonym Symbols:EXTR2  
NCBI Protein Information:exostosin-like 2
UniProt Protein Name:Exostosin-like 2
UniProt Synonym Protein Names:Alpha-1,4-N-acetylhexosaminyltransferase EXTL2; Alpha-GalNAcT EXTL2; EXT-related protein 2; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Protein Family:Exostosin
UniProt Gene Name:EXTL2  
UniProt Entry Name:EXTL2_HUMAN
Anti-EXTL2 Antibody (CAB15669)Western blot analysis of extracts of various cell lines, using EXTL2 antibody (CAB15669) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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