Epigenetics & Nuclear Signaling Antibodies 3

Anti-EXOSC8 Antibody (CAB4507)

(No reviews yet) Write a Review
SKU:
CAB4507
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EXOSC8
Synonyms:
CIP3
Synonyms:
EAP2
Synonyms:
OIP2
Synonyms:
PCH1C
Synonyms:
RRP43
Synonyms:
Rrp43p
Synonyms:
bA421P11.3
Synonyms:
p9
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:EXOSC8 Rabbit pAb
Product Code:CAB4507
Size:20uL, 50uL, 100uL
Synonyms:EXOSC8, CIP3, EAP2, OIP2, PCH1C, RRP43, Rrp43p, bA421P11.3, p9
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human EXOSC8 (NP_852480.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, HL-60, MCF7, SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human EXOSC8 (NP_852480.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAG FKTV EPLE YYRR FLKE NCRP DGRE LGEF RTTT VNIG SIST ADGS ALVK LGNT TVIC GVKA EFAA PSTD APDK GYVV PNVD LPPL CSSR FRSG PPGE EAQV ASQF IADV IENS QIIQ KEDL CISP GKLV WVLY CDLI CLDY DGNI LDAC TFAL LAAL KNVQ LPEV TINE ETAL AEVN LKKK SYLN IRTH PVAT SFAV FDDT LLIV DPTG EEEH LATG TLTI VMDE EGKL CCLH KPGG SGLT GAKL QDCM SRAV TRHK EVKK LMDE VIKS MKPK
Gene ID:11340
Uniprot:Q96B26
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:30kDa
Observed MW:35kDa
UniProt Protein Function:EXOSC8: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. Belongs to the RNase PH family.
UniProt Protein Details:

Protein type:Nucleolus; EC 3.1.13.-; Ribonuclease

Chromosomal Location of Human Ortholog: 13q13.1

Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); nucleus; cytosol

Molecular Function:protein binding; exoribonuclease activity; AU-rich element binding

Biological Process: gene expression; rRNA processing; mRNA catabolic process, deadenylation-dependent decay

Disease: Pontocerebellar Hypoplasia, Type 1c

NCBI Summary:This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
UniProt Code:Q96B26
NCBI GenInfo Identifier:21759409
NCBI Gene ID:11340
NCBI Accession:Q96B26.1
UniProt Secondary Accession:Q96B26,O43480, Q5TBA5,
UniProt Related Accession:Q96B26
Molecular Weight:276
NCBI Full Name:Exosome complex component RRP43
NCBI Synonym Full Names:exosome component 8
NCBI Official Symbol:EXOSC8  
NCBI Official Synonym Symbols:p9; CIP3; EAP2; OIP2; PCH1C; RRP43; Rrp43p; bA421P11.3  
NCBI Protein Information:exosome complex component RRP43; OIP-2; CBP-interacting protein 3; Opa interacting protein 2; opa-interacting protein 2; exosome complex exonuclease RRP43; ribosomal RNA-processing protein 43
UniProt Protein Name:Exosome complex component RRP43
UniProt Synonym Protein Names:Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9
Protein Family:Exosome complex component
UniProt Gene Name:EXOSC8  
UniProt Entry Name:EXOS8_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products