Epigenetics & Nuclear Signaling Antibodies 4
Anti-EXOSC7 Antibody (CAB9689)
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- SKU:
- CAB9689
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-EXOSC7 Antibody |
| Antibody SKU: | CAB9689 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-291 of human EXOSC7 (NP_055819.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, SKOV3, K-562, Jurkat, MCF7, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-291 of human EXOSC7 (NP_055819.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASV TLSE AEKV YIVH GVQE DLRV DGRG CEDY RCVE VETD VVSN TSGS ARVK LGHT DILV GVKA EMGT PKLE KPNE GYLE FFVD CSAS ATPE FEGR GGDD LGTE IANT LYRI FNNK SSVD LKTL CISP REHC WVLY VDVL LLEC GGNL FDAI SIAV KAAL FNTR IPRV RVLE DEEG SKDI ELSD DPYD CIRL SVEN VPCI VTLC KIGY RHVV DATL QEEA CSLA SLLV SVTS KGVV TCMR KVGK GSLD PESI FEMM ETGK RVGK VLHA SLQS VVHK EESL GPKR QKVG FLG |
| Gene ID: | 23016 |
| Uniprot: | Q15024 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 31kDa |
| Observed MW: | 37kDa |
| Synonyms: | EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8 |
| Background: |
| UniProt Protein Function: | EXOSC7: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family. |
| UniProt Protein Details: | Protein type:EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleoplasm; nucleus Molecular Function:3'-5'-exoribonuclease activity; AU-rich element binding; exoribonuclease activity; protein binding; RNA binding Biological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of mRNA stability; rRNA processing |
| UniProt Code: | Q15024 |
| NCBI GenInfo Identifier: | 189083688 |
| NCBI Gene ID: | 23016 |
| NCBI Accession: | NP_055819 |
| UniProt Secondary Accession: | Q15024,Q96E72, |
| UniProt Related Accession: | Q15024 |
| Molecular Weight: | 34.2 kDa (314aa) confirmed by MALDI-TOF |
| NCBI Full Name: | exosome complex component RRP42 |
| NCBI Synonym Full Names: | exosome component 7 |
| NCBI Official Symbol: | EXOSC7 |
| NCBI Official Synonym Symbols: | p8; EAP1; RRP42; Rrp42p; hRrp42p |
| NCBI Protein Information: | exosome complex component RRP42 |
| UniProt Protein Name: | Exosome complex component RRP42 |
| UniProt Synonym Protein Names: | Exosome component 7; Ribosomal RNA-processing protein 42; p8 |
| Protein Family: | Exosome complex exonuclease |
| UniProt Gene Name: | EXOSC7 |
| UniProt Entry Name: | EXOS7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EXOSC7 antibody (CAB9689) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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