Anti-EXOSC7 Antibody (CAB0341)

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CAB0341

Description

Product Name:EXOSC7 Rabbit mAb
Product Code:CAB0341
Size:20uL, 50uL, 100uL
Synonyms:EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, exosome component 7
Applications:WB, IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human EXOSC7.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HepG2, A-431, K-562, U-251MG
Immunogen:A synthesized peptide derived from human EXOSC7.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23016
Uniprot:Q15024
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:32kDa
Observed MW:37KDa
UniProt Protein Function:EXOSC7: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.
UniProt Protein Details:

Protein type:EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleoplasm; nucleus

Molecular Function:3'-5'-exoribonuclease activity; AU-rich element binding; exoribonuclease activity; protein binding; RNA binding

Biological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of mRNA stability; rRNA processing

UniProt Code:Q15024
NCBI GenInfo Identifier:189083688
NCBI Gene ID:23016
NCBI Accession:NP_055819
UniProt Secondary Accession:Q15024,Q96E72,
UniProt Related Accession:Q15024
Molecular Weight:34.2 kDa (314aa) confirmed by MALDI-TOF
NCBI Full Name:exosome complex component RRP42
NCBI Synonym Full Names:exosome component 7
NCBI Official Symbol:EXOSC7  
NCBI Official Synonym Symbols:p8; EAP1; RRP42; Rrp42p; hRrp42p  
NCBI Protein Information:exosome complex component RRP42
UniProt Protein Name:Exosome complex component RRP42
UniProt Synonym Protein Names:Exosome component 7; Ribosomal RNA-processing protein 42; p8
Protein Family:Exosome complex exonuclease
UniProt Gene Name:EXOSC7  
UniProt Entry Name:EXOS7_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
EXOSC7
Synonyms:
EAP1
Synonyms:
RRP42
Synonyms:
Rrp42p
Synonyms:
hRrp42p
Synonyms:
p8
Synonyms:
exosome component 7
Research Area:
Epigenetics and Nuclear Signaling
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