Cell Biology Antibodies 13

Anti-EXOSC6 Antibody (CAB17252)

(No reviews yet) Write a Review
SKU:
CAB17252
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-EXOSC6 Antibody
Antibody SKU:CAB17252
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human EXOSC6.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:A synthetic peptide of human EXOSC6.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:118460
Uniprot:Q5RKV6
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:EXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11
Background:This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
UniProt Protein Function:EXOSC6: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.
UniProt Protein Details:

Protein type:Nucleolus; EC 3.1.13.-; Ribonuclease

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytosol; exosome (RNase complex); nuclear exosome (RNase complex); nucleolus; nucleoplasm

Molecular Function:exoribonuclease activity

Biological Process: DNA deamination; isotype switching; regulation of mRNA stability; rRNA 3'-end processing; rRNA catabolic process; rRNA processing

NCBI Summary:This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
UniProt Code:Q5RKV6
NCBI GenInfo Identifier:74736141
NCBI Gene ID:118460
NCBI Accession:Q5RKV6.1
UniProt Related Accession:Q5RKV6
Molecular Weight:28,235 Da
NCBI Full Name:Exosome complex component MTR3
NCBI Synonym Full Names:exosome component 6
NCBI Official Symbol:EXOSC6  
NCBI Official Synonym Symbols:p11; EAP4; MTR3; Mtr3p; hMtr3p  
NCBI Protein Information:exosome complex component MTR3
UniProt Protein Name:Exosome complex component MTR3
UniProt Synonym Protein Names:Exosome component 6; mRNA transport regulator 3 homolog; hMtr3; p11
UniProt Gene Name:EXOSC6  
UniProt Entry Name:EXOS6_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products