Cell Biology Antibodies 8

Anti-EXOG Antibody (CAB3364)

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SKU:
CAB3364
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EXOG Antibody
Antibody SKU:CAB3364
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 144-368 of human EXOG (NP_005098.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, SW620, MCF7, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 144-368 of human EXOG (NP_005098.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AGNN KFSS KAMA ETFY LSNI VPQD FDNN SGYW NRIE MYCR ELTE RFED VWVV SGPL TLPQ TRGD GKKI VSYQ VIGE DNVA VPSH LYKV ILAR RSSV STEP LALG AFVV PNEA IGFQ PQLT EFQV SLQD LEKL SGLV FFPH LDRT SDIR NICS VDTC KLLD FQEF TLYL STRK IEGA RSVL RLEK IMEN LKNA EIEP DDYF MSRY EKKL EELK AKEQ SGTQ IRKP S
Gene ID:9941
Uniprot:Q9Y2C4
Cellular Location:Mitochondrion inner membrane
Calculated MW:16kDa/26kDa/35kDa/41kDa
Observed MW:41kDa
Synonyms:EXOG, ENDOGL1, ENDOGL2, ENGL, ENGL-a, ENGL-b, ENGLA, ENGLB
Background:This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18.
UniProt Protein Function:ENDOGL1: Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity. Belongs to the DNA/RNA non-specific endonuclease family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; Deoxyribonuclease; Ribonuclease; EC 3.1.30.-

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: mitochondrion; mitochondrial inner membrane

Molecular Function:nucleic acid binding; metal ion binding; endonuclease activity

Biological Process: DNA catabolic process, endonucleolytic

NCBI Summary:This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
UniProt Code:Q9Y2C4
NCBI GenInfo Identifier:193806336
NCBI Gene ID:9941
NCBI Accession:Q9Y2C4.2
UniProt Secondary Accession:Q9Y2C4,Q3SXM9, Q9Y2C8, A8K242, B4DVG2,
UniProt Related Accession:Q9Y2C4
Molecular Weight:368
NCBI Full Name:Nuclease EXOG, mitochondrial
NCBI Synonym Full Names:endo/exonuclease (5'-3'), endonuclease G-like
NCBI Official Symbol:EXOG  
NCBI Official Synonym Symbols:ENGL; ENGLA; ENGLB; ENGL-a; ENGL-b; ENDOGL1; ENDOGL2  
NCBI Protein Information:nuclease EXOG, mitochondrial; endo G-like 1; endonuclease G-like 1; endonuclease G-like 2
UniProt Protein Name:Nuclease EXOG, mitochondrial
UniProt Synonym Protein Names:Endonuclease G-like 1; Endo G-like 1
Protein Family:Exoglucanase
UniProt Gene Name:EXOG  
UniProt Entry Name:EXOG_HUMAN
Anti-EXOG Antibody (CAB3364)Western blot analysis of extracts of various cell lines, using EXOG antibody (CAB3364) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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