Cell Biology Antibodies 12
Anti-EXOC5 Antibody (CAB9282)
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- SKU:
- CAB9282
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-EXOC5 Antibody |
| Antibody SKU: | CAB9282 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human EXOC5 (NP_006535.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, THP-1, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 340-610 of human EXOC5 (NP_006535.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SIFI SYLE NYIE VETG YLKS RSAM ILQR YYDS KNHQ KRSI GTGG IQDL KERI RQRT NLPL GPSI DTHG ETFL SQEV VVNL LQET KQAF ERCH RLSD PSDL PRNA FRIF TILV EFLC IEHI DYAL ETGL AGIP SSDS RNAN LYFL DVVQ QANT IFHL FDKQ FNDH LMPL ISSS PKLS ECLQ KKKE IIEQ MEMK LDTG IDRT LNCM IGQM KHIL AAEQ KKTD FKPE DENN VLIQ YTNA CVKV CAYV RKQV EKIK NSMD GKNV DTVL MELG VRF |
| Gene ID: | 10640 |
| Uniprot: | O00471 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 81kDa |
| Observed MW: | 82kDa |
| Synonyms: | EXOC5, HSEC10, PRO1912, SEC10, SEC10L1, SEC10P |
| Background: | The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. |
| UniProt Protein Function: | EXOC5: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC10 family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 14q22.3 Cellular Component: cytoplasm; cytosol Molecular Function:Ral GTPase binding Biological Process: post-Golgi vesicle-mediated transport |
| NCBI Summary: | The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00471 |
| NCBI GenInfo Identifier: | 24418661 |
| NCBI Gene ID: | 10640 |
| NCBI Accession: | O00471.1 |
| UniProt Secondary Accession: | O00471,B2R6C5, |
| UniProt Related Accession: | O00471 |
| Molecular Weight: | 81,853 Da |
| NCBI Full Name: | Exocyst complex component 5 |
| NCBI Synonym Full Names: | exocyst complex component 5 |
| NCBI Official Symbol: | EXOC5 |
| NCBI Official Synonym Symbols: | SEC10; HSEC10; SEC10P; PRO1912; SEC10L1 |
| NCBI Protein Information: | exocyst complex component 5 |
| UniProt Protein Name: | Exocyst complex component 5 |
| UniProt Synonym Protein Names: | Exocyst complex component Sec10; hSec10 |
| Protein Family: | Exocyst complex component |
| UniProt Gene Name: | EXOC5 |
| UniProt Entry Name: | EXOC5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EXOC5 antibody (CAB9282) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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