Epigenetics & Nuclear Signaling Antibodies 2

Anti-ETV6 Antibody (CAB15668)

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SKU:
CAB15668
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ETV6 Antibody
Antibody SKU:CAB15668
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse lung, Mouse spleen, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSET PAQC SIKQ ERIS YTPP ESPV PSYA SSTP LHVP VPRA LRME EDSI RLPA HLRL QPIY WSRD DVAQ WLKW AENE FSLR PIDS NTFE MNGK ALLL LTKE DFRY RSPH SGDV LYEL LQHI LKQR KPRI LFSP FFHP GNSI HTQP EVIL HQNH EEDN CVQR TPRP SVDN VHHN PPTI ELLH RSRS PITT NHRP SPDP EQRP LRSP LDNM IRRL SPAE RAQG PRPH QENN HQES YPLS VSPM ENNH CPAS SESH PKPS SPRQ ESTR VIQL MPSP IMHP LILN PRHS VDFK QSRL SEDG LHRE
Gene ID:2120
Uniprot:P41212
Cellular Location:Nucleus
Calculated MW:53kDa
Observed MW:55kDa
Synonyms:ETV6, TEL, TEL/ABL, THC5
Background:This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
UniProt Protein Function:Tel: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE). A hematologic disorder characterized by malignant eosinophils proliferation. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. Belongs to the ETS family.
UniProt Protein Details:

Protein type:Transcription factor; Oncoprotein; Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:protein binding; protein domain specific binding; transcription factor activity

Biological Process: cell differentiation; negative regulation of transcription from RNA polymerase II promoter

Disease: Thrombocytopenia 5

NCBI Summary:This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
UniProt Code:P41212
NCBI GenInfo Identifier:730927
NCBI Gene ID:2120
NCBI Accession:P41212.1
UniProt Secondary Accession:P41212,Q9UMF6, Q9UMF7, Q9UMG0, A3QVP6, A8K076,
UniProt Related Accession:P41212
Molecular Weight:53,000 Da
NCBI Full Name:Transcription factor ETV6
NCBI Synonym Full Names:ETS variant 6
NCBI Official Symbol:ETV6  
NCBI Official Synonym Symbols:TEL; THC5; TEL/ABL  
NCBI Protein Information:transcription factor ETV6
UniProt Protein Name:Transcription factor ETV6
UniProt Synonym Protein Names:ETS translocation variant 6; ETS-related protein Tel1; Tel
Protein Family:Transcription factor
UniProt Gene Name:ETV6  
UniProt Entry Name:ETV6_HUMAN
Anti-ETV6 Antibody (CAB15668)Western blot analysis of extracts of various cell lines, using ETV6 antibody (CAB15668) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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