Epigenetics & Nuclear Signaling Antibodies 4
Anti-ETS2 Antibody (CAB7329)
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- SKU:
- CAB7329
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ETS2 Antibody |
| Antibody SKU: | CAB7329 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-350 of human ETS2 (NP_005230.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-431, mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-350 of human ETS2 (NP_005230.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WEHL EQMI KENQ EKTE DQYE ENSH LTSV PHWI NSNT LGFG TEQA PYGM QTQN YPKG GLLD SMCP ASTP SVLS SEQE FQMF PKSR LSSV SVTY CSVS QDFP GSNL NLLT NNSG TPKD HDSP ENGA DSFE SSDS LLQS WNSQ SSLL DVQR VPSF ESFE DDCS QSLC LNKP TMSF KDYI QERS DPVE QGKP VIP |
| Gene ID: | 2114 |
| Uniprot: | P15036 |
| Cellular Location: | Nucleus |
| Calculated MW: | 53kDa |
| Observed MW: | 53kDa |
| Synonyms: | ETS2, ETS2IT1 |
| Background: | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Ets-2: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus E26 oncogene. A target of the Akt/JNK signaling pathway in macrophages. A PKC pathway activates ETS2, up-regulating GM-CSF in non-small lung carcinoma cells. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 21q22.2 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity; glucocorticoid receptor binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; skeletal development |
| NCBI Summary: | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P15036 |
| NCBI GenInfo Identifier: | 119645 |
| NCBI Gene ID: | 2114 |
| NCBI Accession: | P15036.1 |
| UniProt Secondary Accession: | P15036,A1A4L6, |
| UniProt Related Accession: | P15036 |
| Molecular Weight: | 469 |
| NCBI Full Name: | Protein C-ets-2 |
| NCBI Synonym Full Names: | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
| NCBI Official Symbol: | ETS2 |
| NCBI Official Synonym Symbols: | ETS2IT1 |
| NCBI Protein Information: | protein C-ets-2; oncogene ETS-2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets avian erythroblastosis virus E2 oncogene homolog 2 |
| UniProt Protein Name: | Protein C-ets-2 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS2 |
| UniProt Entry Name: | ETS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SPRY3 antibody (CAB7329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of U-2 OS cells using ETS2 antibody (CAB7329) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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