Epigenetics & Nuclear Signaling Antibodies 3

Anti-ETS2 Antibody (CAB14486)

(No reviews yet) Write a Review
SKU:
CAB14486
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ETS2 Antibody
Antibody SKU:CAB14486
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-345 of human ETS2 (NP_005230.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-345 of human ETS2 (NP_005230.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QMIK ENQE KTED QYEE NSHL TSVP HWIN SNTL GFGT EQAP YGMQ TQNY PKGG LLDS MCPA STPS VLSS EQEF QMFP KSRL SSVS VTYC SVSQ DFPG SNLN LLTN NSGT PKDH DSPE NGAD SFES SDSL LQSW NSQS SLLD VQRV PSFE SFED DCSQ SLCL NKPT MSFK DYIQ ERSD PVEQ G
Gene ID:2114
Uniprot:P15036
Cellular Location:Nucleus
Calculated MW:53kDa
Observed MW:Refer to Figures
Synonyms:ETS2, ETS2IT1
Background:This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Ets-2: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus E26 oncogene. A target of the Akt/JNK signaling pathway in macrophages. A PKC pathway activates ETS2, up-regulating GM-CSF in non-small lung carcinoma cells.
UniProt Protein Details:

Protein type:Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; DNA binding; transcription factor activity; glucocorticoid receptor binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; skeletal development

NCBI Summary:This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Code:P15036
NCBI GenInfo Identifier:119645
NCBI Gene ID:2114
NCBI Accession:P15036.1
UniProt Secondary Accession:P15036,A1A4L6,
UniProt Related Accession:P15036
Molecular Weight:469
NCBI Full Name:Protein C-ets-2
NCBI Synonym Full Names:v-ets avian erythroblastosis virus E26 oncogene homolog 2
NCBI Official Symbol:ETS2  
NCBI Official Synonym Symbols:ETS2IT1  
NCBI Protein Information:protein C-ets-2; oncogene ETS-2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets avian erythroblastosis virus E2 oncogene homolog 2
UniProt Protein Name:Protein C-ets-2
Protein Family:Protein
UniProt Gene Name:ETS2  
UniProt Entry Name:ETS2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products