Epigenetics & Nuclear Signaling Antibodies 3

Anti-ESRRG Antibody (CAB3853)

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SKU:
CAB3853
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ESRRG Antibody
Antibody SKU:CAB3853
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ESRRG (NP_001429.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ESRRG (NP_001429.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AFFK RTIQ GNIE YSCP ATNE CEIT KRRR KSCQ ACRF MKCL KVGM LKEG VRLD RVRG GRQK YKRR IDAE NSPY LNPQ LVQP AKKP YNKI VSHL LVAE PEKI Y
Gene ID:2104
Uniprot:P62508
Cellular Location:Nucleus
Calculated MW:44kDa/48kDa/49kDa/51kDa/52kDa
Observed MW:60kDa
Synonyms:ESRRG, ERR3, ERRgamma, NR3B3
Background:This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
UniProt Protein Function:ERR3: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: nucleoplasm

Molecular Function:AF-2 domain binding; protein binding

Biological Process: positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
UniProt Code:P62508
NCBI GenInfo Identifier:50402102
NCBI Gene ID:2104
NCBI Accession:P62508.1
UniProt Secondary Accession:P62508,O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38 A8K4I0, A8K6I2, B3KY84, E9PGB7, F8W8J3,
UniProt Related Accession:P62508
Molecular Weight:52,462 Da
NCBI Full Name:Estrogen-related receptor gamma
NCBI Synonym Full Names:estrogen related receptor gamma
NCBI Official Symbol:ESRRG  
NCBI Official Synonym Symbols:ERR3; NR3B3; ERRgamma  
NCBI Protein Information:estrogen-related receptor gamma
UniProt Protein Name:Estrogen-related receptor gamma
UniProt Synonym Protein Names:ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3
Protein Family:Estrogen-related receptor
UniProt Gene Name:ESRRG  
UniProt Entry Name:ERR3_HUMAN
Anti-ESRRG Antibody (CAB3853)Western blot analysis of extracts of mouse brain, using ESRRG antibody (CAB3853) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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