Epigenetics & Nuclear Signaling Antibodies 3

Anti-ESRRB Antibody (CAB13977)

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SKU:
CAB13977
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ESRRB Antibody
Antibody SKU:CAB13977
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ESRRB (NP_004443.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ESRRB (NP_004443.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VYAE DYIM DEEH SRLA GLLE LYRA ILQL VRRY KKLK VEKE EFVT LKAL ALAN SDSM YIED LEAV QKLQ DLLH EALQ DYEL SQRH EEPW RTGK LLLT LPLL R
Gene ID:2103
Uniprot:O95718
Cellular Location:Nucleus
Calculated MW:48kDa/55kDa/56kDa
Observed MW:50kDa
Synonyms:ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2
Background:This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.
UniProt Protein Function:ERR2: Nuclear receptor, may regulate ESR1 transcriptional activity. Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35). DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; nucleus

Molecular Function:ligand-dependent nuclear receptor activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter

Disease: Deafness, Autosomal Recessive 35

NCBI Summary:This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]
UniProt Code:O95718
NCBI GenInfo Identifier:374095385
NCBI Gene ID:2103
NCBI Accession:O95718.2
UniProt Secondary Accession:O95718,Q5F0P7, Q5F0P8, Q9HCB4, A2VDJ2, B6ZGU4,
UniProt Related Accession:O95718
Molecular Weight:48,054 Da
NCBI Full Name:Steroid hormone receptor ERR2
NCBI Synonym Full Names:estrogen related receptor beta
NCBI Official Symbol:ESRRB  
NCBI Official Synonym Symbols:ERR2; ERRb; ESRL2; NR3B2; DFNB35  
NCBI Protein Information:steroid hormone receptor ERR2
UniProt Protein Name:Steroid hormone receptor ERR2
UniProt Synonym Protein Names:ERR beta-2; Estrogen receptor-like 2; Estrogen-related receptor beta; ERR-beta; Nuclear receptor subfamily 3 group B member 2
Protein Family:Steroid hormone receptor
UniProt Gene Name:ESRRB  
UniProt Entry Name:ERR2_HUMAN
Anti-ESRRB Antibody (CAB13977)Western blot analysis of extracts of various cell lines, using ESRRB antibody (CAB13977) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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