Epigenetics & Nuclear Signaling Antibodies 3
Anti-ESRRA Antibody (CAB1798)
(No reviews yet)
Write a Review
- SKU:
- CAB1798
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ESRRA Antibody |
| Antibody SKU: | CAB1798 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human ESRRA (NP_004442.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, HT-29, BT-474, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human ESRRA (NP_004442.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSQ VVGI EPLY IKAE PASP DSPK GSSE TETE PPVA LAPG PAPT RCLP GHKE EEDG EGAG PGEQ GGGK LVLS SLPK RLCL VCGD VASG YHYG VASC EACK AFFK RTIQ GSIE YSCP ASNE CEIT KRRR KACQ ACRF TKCL RVGM LKEG VRLD RVRG GRQK YKRR PEVD PLPF PGPF PAGP LAVA GGPR KTAA PVNA LVSH LLVV EPEK LYAM PDPA GPDG HLPA VATL CDLF DREI VVTI SWAK SIPG FSSL SLSD QMSV LQSV WMEV LVLG VAQR SLPL QDEL AFAE DLVL DEEG ARAA GLGE LGAA LLQL VRRL QALR LERE EYVL LKAL ALAN SDSV HIED AEAV EQLR EALH EALL EYEA GRAG PGGG AERR RAGR LLLT LPLL RQTA GKVL AHFY GVKL EGKV PMHK LFLE MLEA MMD |
| Gene ID: | 2101 |
| Uniprot: | P11474 |
| Cellular Location: | Nucleus |
| Calculated MW: | 45kDa |
| Observed MW: | 53kDa |
| Synonyms: | ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 |
| Background: | The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor Chromosomal Location of Human Ortholog: 11q13 Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; nucleolus; nucleus Molecular Function:protein domain specific binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding Biological Process: transcription initiation from RNA polymerase II promoter; mitochondrion organization and biogenesis; intracellular receptor-mediated signaling pathway; regulation of osteoblast differentiation; organelle organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; cartilage development; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P11474 |
| NCBI GenInfo Identifier: | 215274146 |
| NCBI Gene ID: | 2101 |
| NCBI Accession: | P11474.3 |
| UniProt Related Accession: | P11474 |
| Molecular Weight: | |
| NCBI Full Name: | Steroid hormone receptor ERR1 |
| NCBI Synonym Full Names: | estrogen related receptor alpha |
| NCBI Official Symbol: | ESRRA |
| NCBI Official Synonym Symbols: | ERR1; ERRa; ESRL1; NR3B1; ERRalpha |
| NCBI Protein Information: | steroid hormone receptor ERR1 |
| UniProt Protein Name: | Steroid hormone receptor ERR1 |
| UniProt Synonym Protein Names: | Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1 |
| Protein Family: | Enolase-related protein |
| UniProt Gene Name: | ESRRA |
| UniProt Entry Name: | ERR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ESRRA antibody (CAB1798) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
View AllClose
Related Products
