Cell Biology Antibodies 17
Anti-ERp57 Antibody (CAB4376)
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- SKU:
- CAB4376
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ER60
- Synonyms:
- ERp57
- Synonyms:
- ERp60
- Synonyms:
- ERp61
- Synonyms:
- GRP57
- Synonyms:
- GRP58
- Synonyms:
- HEL-S-269
- Synonyms:
- HEL-S-93n
- Synonyms:
- HsT17083
- Synonyms:
- P58
- Synonyms:
- PI-PLC
- Research Area:
- Cell Biology
Description
| Product Name: | ERp57 Rabbit mAb |
| Product Code: | CAB4376 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ERp57 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | 293T, HepG2 |
| Immunogen: | A synthesized peptide derived from human ERp57 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2923 |
| Uniprot: | P30101 |
| Cellular Location: | Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome |
| Calculated MW: | 57kDa |
| Observed MW: | 57KDa |
| UniProt Protein Function: | GRP58: a protein disulfide isomerase found in the endoplasmic reticulum lumen. Catalyzes the rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures. An essential component of the peptide-loading complex of the major histocompatibility complex class I pathway. |
| UniProt Protein Details: | Protein type:Chaperone; Endoplasmic reticulum; Protease; Isomerase; EC 5.3.4.1; Apoptosis; Phospholipase Chromosomal Location of Human Ortholog: 15q15 Cellular Component: smooth endoplasmic reticulum; cell surface; focal adhesion; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome; nucleus Molecular Function:disulfide oxidoreductase activity; protein binding; cysteine-type endopeptidase activity; protein disulfide isomerase activity; phospholipase C activity Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; protein import into nucleus; cell redox homeostasis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein amino acid N-linked glycosylation via asparagine; signal transduction; proteolysis; post-translational protein modification; protein retention in ER |
| NCBI Summary: | This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30101 |
| NCBI GenInfo Identifier: | 2507461 |
| NCBI Gene ID: | 2923 |
| NCBI Accession: | P30101.4 |
| UniProt Secondary Accession: | P30101,Q13453, Q14255, Q8IYF8, Q9UMU7, |
| UniProt Related Accession: | P30101,AAB37397 |
| Molecular Weight: | 56,782 Da |
| NCBI Full Name: | Protein disulfide-isomerase A3 |
| NCBI Synonym Full Names: | protein disulfide isomerase family A, member 3 |
| NCBI Official Symbol: | PDIA3 |
| NCBI Official Synonym Symbols: | P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n |
| NCBI Protein Information: | protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; epididymis secretory protein Li 269; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 93n |
| UniProt Protein Name: | Protein disulfide-isomerase A3 |
| UniProt Synonym Protein Names: | 58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60 |
| Protein Family: | Protein disulfide-isomerase |
| UniProt Gene Name: | PDIA3 |
| UniProt Entry Name: | PDIA3_HUMAN |
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