Metabolism Antibodies 2
Anti-ERP44 Antibody (CAB4526)
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- SKU:
- CAB4526
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ERP44
- Synonyms:
- PDIA10
- Synonyms:
- TXNDC4
- Research Area:
- Metabolism
Description
| Product Name: | ERP44 Rabbit pAb |
| Product Code: | CAB4526 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ERP44, PDIA10, TXNDC4 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-406 of human ERP44 (NP_055866.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, U-87MG, HepG2, Mouse kidney, Rat Pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 57-406 of human ERP44 (NP_055866.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WCRF SQML HPIF EEAS DVIK EEFP NENQ VVFA RVDC DQHS DIAQ RYRI SKYP TLKL FRNG MMMK REYR GQRS VKAL ADYI RQQK SDPI QEIR DLAE ITTL DRSK RNII GYFE QKDS DNYR VFER VANI LHDD CAFL SAFG DVSK PERY SGDN IIYK PPGH SAPD MVYL GAMT NFDV TYNW IQDK CVPL VREI TFEN GEEL TEEG LPFL ILFH MKED TESL EIFQ NEVA RQLI SEKG TINF LHAD CDKF RHPL LHIQ KTPA DCPV IAID SFRH MYVF GDFK DVLI PGKL KQFV FDLH SGKL HREF HHGP DPTD TAPG EQAQ DVAS SPPE SSFQ KLAP SEYR YTLL RDRD EL |
| Gene ID: | 23071 |
| Uniprot: | Q9BS26 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 46kDa |
| Observed MW: | 40-48kDa |
| UniProt Protein Function: | ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Endoplasmic reticulum; Secreted; Isomerase Chromosomal Location of Human Ortholog: 9q31.1 Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein |
| NCBI Summary: | This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q9BS26 |
| NCBI GenInfo Identifier: | 31077035 |
| NCBI Gene ID: | 23071 |
| NCBI Accession: | Q9BS26.1 |
| UniProt Related Accession: | Q9BS26 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | Endoplasmic reticulum resident protein 44 |
| NCBI Synonym Full Names: | endoplasmic reticulum protein 44 |
| NCBI Official Symbol: | ERP44 |
| NCBI Official Synonym Symbols: | PDIA10; TXNDC4 |
| NCBI Protein Information: | endoplasmic reticulum resident protein 44 |
| UniProt Protein Name: | Endoplasmic reticulum resident protein 44 |
| UniProt Synonym Protein Names: | Thioredoxin domain-containing protein 4 |
| Protein Family: | Endoplasmic reticulum resident protein |
| UniProt Gene Name: | ERP44 |
| UniProt Entry Name: | ERP44_HUMAN |
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