Anti-Erlin-2 Antibody (CAB0781)
- SKU:
- CAB0781
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ERLIN2
- Synonyms:
- C8orf2
- Synonyms:
- NET32
- Synonyms:
- SPFH2
- Synonyms:
- SPG18
- Research Area:
- Metabolism
Description
| Product Name: | Erlin-2 Rabbit mAb |
| Product Code: | CAB0781 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ERLIN2, C8orf2, Erlin-2, NET32, SPFH2, SPG18, erlin-2 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Erlin-2. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, PC-3, OVCAR3, C2C12 |
| Immunogen: | A synthesized peptide derived from human Erlin-2. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11160 |
| Uniprot: | O94905 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
| Calculated MW: | 38kDa |
| Observed MW: | 43KDa |
| UniProt Protein Function: | SPFH2: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Forms a heteromeric complex with ERLIN1. Ubiquitous. Belongs to the band 7/mec-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; lipid raft; plasma membrane; protein complex Molecular Function:cholesterol binding; protein binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway Disease: Spastic Paraplegia 18, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | O94905 |
| NCBI GenInfo Identifier: | 38257366 |
| NCBI Gene ID: | 11160 |
| NCBI Accession: | O94905.1 |
| UniProt Secondary Accession: | O94905,Q6NW21, Q86VS6, Q86W49, A0JLQ1, A8K5S9, B4DM38 D3DSW0, |
| UniProt Related Accession: | O94905 |
| Molecular Weight: | 22,939 Da |
| NCBI Full Name: | Erlin-2 |
| NCBI Synonym Full Names: | ER lipid raft associated 2 |
| NCBI Official Symbol: | ERLIN2 |
| NCBI Official Synonym Symbols: | NET32; SPFH2; SPG18; C8orf2; Erlin-2 |
| NCBI Protein Information: | erlin-2 |
| UniProt Protein Name: | Erlin-2 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH domain-containing protein 2 |
| Protein Family: | Erlin |
| UniProt Gene Name: | ERLIN2 |
| UniProt Entry Name: | ERLN2_HUMAN |
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