| Background: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ERK5: a protein kinase of the MAPK family. Phosphorylated and activated by MEK5. Involved in the signaling processes downstream of various receptors including receptor tyrosine kinases and G protein-coupled receptors. Translocates to cell nucleus in response to extracelluar signals, where it regulates gene expression by phosphorylating various transcription factors. Mouse knockout shows a role in development and integrity of blood vessels. May block apoptosis in endothelial cells. Required for transduction of EGF growth signal, constitutively activated in ErbB2-overexpressing breast cancer, and downstream of activated Mek5 in metastatic prostate cancerFour alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleoplasm; PML body; cytoplasm; nucleus; cytosol Molecular Function:MAP kinase activity; protein binding; mitogen-activated protein kinase binding; ATP binding Biological Process: nerve growth factor receptor signaling pathway; negative regulation of cAMP catabolic process; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; positive regulation of protein metabolic process; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; cAMP-mediated signaling; cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of heterotypic cell-cell adhesion; MyD88-independent toll-like receptor signaling pathway; cell cycle; negative regulation of NFAT protein import into nucleus; regulation of angiogenesis; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; negative regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of cyclic-nucleotide phosphodiesterase activity |
| NCBI Summary: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13164 |
| NCBI GenInfo Identifier: | 205371766 |
| NCBI Gene ID: | 5598 |
| NCBI Accession: | Q13164.2 |
| UniProt Secondary Accession: | Q13164,Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51 |
| UniProt Related Accession: | Q13164 |
| Molecular Weight: | 50,152 Da |
| NCBI Full Name: | Mitogen-activated protein kinase 7 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase 7 |
| NCBI Official Symbol: | MAPK7 |
| NCBI Official Synonym Symbols: | BMK1; ERK4; ERK5; PRKM7 |
| NCBI Protein Information: | mitogen-activated protein kinase 7; BMK-1; BMK1 kinase; ERK-5; MAP kinase 7; MAPK 7; big MAP kinase 1; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5 |
| UniProt Protein Name: | Mitogen-activated protein kinase 7 |
| UniProt Synonym Protein Names: | Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5 |
| UniProt Gene Name: | MAPK7 |
| UniProt Entry Name: | MK07_HUMAN |
