Epigenetics & Nuclear Signaling Antibodies 1

Anti-ERCC6L2 Antibody (CAB13144)

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SKU:
CAB13144
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ERCC6L2 Antibody
Antibody SKU:CAB13144
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1262-1561 of human ERCC6L2 (NP_064592.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, HeLa, LO2, MCF-7, Mouse testis, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1262-1561 of human ERCC6L2 (NP_064592.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TSEE RQKM LRDF YASQ YPEV KEFF VDSV SQFN NSSF EKGE QRTR KKSD KRES LIKP RLSD SETL SFKD STNK ISQV CSLK TYKR KSVK FQNH ISYR EEVF FNDA ETKK SPVS STQE IDSG KNSQ ASED TVTS RSLN SESE TRER RLEN TMKD QQDL TRTG ISRK EPLL KLEN KKIE NPVL ENTS VISL LGDT SILD DLFK SHGN SPTQ LPKK VLSG PMEK AKQR PKDF WDIL NEQN DESL SKLT DLAV IETL CEKA PLAA PFKR REEP ATSL WKSN EKFL WKKF SPSD TDEN ATNT QSTT
Gene ID:375748
Uniprot:Q5T890
Cellular Location:Cytoplasm, Mitochondrion, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:60kDa/81kDa/177kDa
Observed MW:81kDa
Synonyms:ERCC6L2, BMFS2, C9orf102, RAD26L, SR278
Background:This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described.
UniProt Protein Function:May be involved in early DNA damage response.
UniProt Code:Q5T890
NCBI GenInfo Identifier:58219008
NCBI Gene ID:375748
NCBI Accession:NP_001010895.1
UniProt Secondary Accession:Q5T890,Q49AM9, Q5T892, Q8N663, Q8N9D0, Q9NPM7, A4D997 B2RTP8,
UniProt Related Accession:Q5T890
Molecular Weight:177,127 Da
NCBI Full Name:DNA excision repair protein ERCC-6-like 2 isoform c
NCBI Synonym Full Names:excision repair cross-complementation group 6-like 2
NCBI Official Symbol:ERCC6L2  
NCBI Official Synonym Symbols:BMFS2; SR278; RAD26L; C9orf102  
NCBI Protein Information:DNA excision repair protein ERCC-6-like 2; stretch responsive protein 278; DNA repair and recombination protein RAD26-like; putative repair and recombination helicase RAD26L; excision repair cross-complementing rodent repair deficiency, complementation gr
UniProt Protein Name:DNA excision repair protein ERCC-6-like 2
UniProt Synonym Protein Names:DNA repair and recombination protein RAD26-like
Protein Family:DNA repair protein
UniProt Gene Name:ERCC6L2  
UniProt Entry Name:ER6L2_HUMAN
Anti-ERCC6L2 Antibody (CAB13144)Western blot analysis of extracts of various cell lines, using ERCC6L2 antibody (CAB13144) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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