Cell Cycle Antibodies 1
Anti-ERCC6L Antibody (CAB6139)
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- SKU:
- CAB6139
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-ERCC6L Antibody |
| Antibody SKU: | CAB6139 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ERCC6L (NP_060139.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, Jurkat, A-549 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ERCC6L (NP_060139.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KDAT PGEK ALGF KISE NLMA IIKP YFLR RTKE DVQK KKSS NPEA RLNE KNPD VDAI CEMP SLSR KNDL IIWI RLVP LQEE IYRK FVSL DHIK ELLM ETRS P |
| Gene ID: | 54821 |
| Uniprot: | Q2NKX8 |
| Cellular Location: | Chromosome, centromere, kinetochore |
| Calculated MW: | 141kDa |
| Observed MW: | 223kDa |
| Synonyms: | ERCC6L, PICH, RAD26L |
| Background: |
| UniProt Protein Function: | PICH: DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Belongs to the SNF2/RAD54 helicase family. |
| UniProt Protein Details: | Protein type:Helicase; EC 3.6.4.12 Chromosomal Location of Human Ortholog: Xq13.1 Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; DNA binding; helicase activity; ATP binding Biological Process: mitosis; metabolic process; cell division; mitotic cell cycle |
| UniProt Code: | Q2NKX8 |
| NCBI GenInfo Identifier: | 121948339 |
| NCBI Gene ID: | 54821 |
| NCBI Accession: | Q2NKX8.1 |
| UniProt Secondary Accession: | Q2NKX8,Q8NCI1, Q96H93, Q9NXQ8, |
| UniProt Related Accession: | Q2NKX8 |
| Molecular Weight: | 1250 |
| NCBI Full Name: | DNA excision repair protein ERCC-6-like |
| NCBI Synonym Full Names: | excision repair cross-complementation group 6-like |
| NCBI Official Symbol: | ERCC6L |
| NCBI Official Synonym Symbols: | PICH; RAD26L |
| NCBI Protein Information: | DNA excision repair protein ERCC-6-like; tumor antigen BJ-HCC-15; SNF2/RAD54 family protein; ATP-dependent helicase ERCC6-like; excision repair protein ERCC6-like; Plk1-interacting checkpoint helicase; excision repair cross-complementing rodent repair def |
| UniProt Protein Name: | DNA excision repair protein ERCC-6-like |
| UniProt Synonym Protein Names: | ATP-dependent helicase ERCC6-like; PLK1-interacting checkpoint helicase; Tumor antigen BJ-HCC-15 |
| UniProt Gene Name: | ERCC6L |
| UniProt Entry Name: | ERC6L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ERCC6L antibody (CAB6139) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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