Cell Biology Antibodies 12
Anti-ERC1 Antibody (CAB9509)
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- SKU:
- CAB9509
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ERC1 Antibody |
| Antibody SKU: | CAB9509 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-850 of human ERC1 (NP_829884.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Jurkat, NIH/3T3, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-850 of human ERC1 (NP_829884.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EIAL EQKK EECL KMES QLKK AHEA ALEA RASP EMSD RIQH LERE ITRY KDES SKAQ AEVD RLLE ILKE VENE KNDK DKKI AELE RQVK DQNK KVAN LKHK EQVE KKKS AQML EEAR RRED NLND SSQQ LQDS LRKK DDRI EELE EALR ESV |
| Gene ID: | 23085 |
| Uniprot: | Q8IUD2 |
| Cellular Location: | Cytoplasm, Golgi apparatus membrane, Membrane, Peripheral membrane protein |
| Calculated MW: | 81kDa/108kDa/113kDa/124kDa/128kDa |
| Observed MW: | 130 120kDa |
| Synonyms: | ERC1, Cast2, ELKS, ERC-1, RAB6IP2 |
| Background: | The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ERC1: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: presynaptic membrane; Golgi membrane; cytoplasm; synapse; IkappaB kinase complex Molecular Function:protein binding; leucine zipper domain binding; Rab GTPase binding; PDZ domain binding Biological Process: protein transport; regulation of transcription, DNA-dependent; multicellular organismal development; I-kappaB phosphorylation; retrograde transport, endosome to Golgi; activation of NF-kappaB transcription factor |
| NCBI Summary: | The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8IUD2 |
| NCBI GenInfo Identifier: | 38045898 |
| NCBI Gene ID: | 23085 |
| NCBI Accession: | NP_829884.1 |
| UniProt Secondary Accession: | Q8IUD2,Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5 Q9UIK7, A2RU77, A7E295, D3DUP7, D3DUP8, |
| UniProt Related Accession: | Q8IUD2 |
| Molecular Weight: | 128,086 Da |
| NCBI Full Name: | ELKS/Rab6-interacting/CAST family member 1 isoform epsilon |
| NCBI Synonym Full Names: | ELKS/RAB6-interacting/CAST family member 1 |
| NCBI Official Symbol: | ERC1 |
| NCBI Official Synonym Symbols: | ELKS; Cast2; RAB6IP2 |
| NCBI Protein Information: | ELKS/Rab6-interacting/CAST family member 1; RAB6 interacting protein 2; Rab6-interacting protein 2 |
| UniProt Protein Name: | ELKS/Rab6-interacting/CAST family member 1 |
| UniProt Synonym Protein Names: | Rab6-interacting protein 2 |
| Protein Family: | ELKS/Rab6-interacting/CAST family |
| UniProt Gene Name: | ERC1 |
| UniProt Entry Name: | RB6I2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ERC1 antibody (CAB9509) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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