Cell Death Antibodies 1
Anti-ERBB4 Antibody (CAB0749)
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- SKU:
- CAB0749
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-ERBB4 Antibody |
| Antibody SKU: | CAB0749 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ERBB4 (NP_005226.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ERBB4 (NP_005226.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YMTP MRDK PKQE YLNP VEEN PFVS RRKN GDLQ ALDN PEYH NASN GPPK AEDE YVNE PLYL NTFA NTLG KAEY LKNN ILSM PEKA KKAF DNPD YWNH SLPP R |
| Gene ID: | 2066 |
| Uniprot: | Q15303 |
| Cellular Location: | Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein |
| Calculated MW: | 143kDa/145kDa/146kDa |
| Observed MW: | 147kDa |
| Synonyms: | ALS19, HER4, p180erbB4, ERBB4, HER4/ErbB4 |
| Background: | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| NCBI Summary: | This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15303 |
| NCBI GenInfo Identifier: | 3913590 |
| NCBI Gene ID: | 2066 |
| NCBI Accession: | |
| UniProt Related Accession: | Q15303 |
| Molecular Weight: | |
| NCBI Full Name: | Receptor tyrosine-protein kinase erbB-4 |
| NCBI Synonym Full Names: | erb-b2 receptor tyrosine kinase 4 |
| NCBI Official Symbol: | ERBB4 |
| NCBI Official Synonym Symbols: | HER4; ALS19; p180erbB4 |
| NCBI Protein Information: | receptor tyrosine-protein kinase erbB-4 |
| UniProt Protein Name: | |
| UniProt Gene Name: |
 | Western blot analysis of extracts of rat brain, using ERBB4 antibody (CAB0749) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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