Cell Biology Antibodies 11

Anti-EPS15L1 Antibody (CAB7828)

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SKU:
CAB7828
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-EPS15L1 Antibody
Antibody SKU:CAB7828
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 475-754 of human EPS15L1 (NP_001245304.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7, HepG2, HeLa, BxPC-3, U-251MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 475-754 of human EPS15L1 (NP_001245304.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QMIS SLKT QIQS QESD LKSQ EDDL NRAK SELN RLQQ EETQ LEQS IQAG RVQL ETII KSLK STQD EINQ ARSK LSQL HESR QEAH RSLE QYDQ VLDG AHGA SLTD LANL SEGV SLAE RGSF GAMD DPFK NKAL LFSN NTQE LHPD PFQT EDPF KSDP FKGA DPFK GDPF QNDP FAEQ QTTS TDPF GGDP FKES DPFR GSAT DDFF KKQT KNDP FTSD PFTK NPSL PSKL DPFE SSDP FSSS SVSS KGSD PFGT LDPF GSGS FNSA EGFA DFSQ MSKV KVHL
Gene ID:58513
Uniprot:Q9UBC2
Cellular Location:Cell membrane, Membrane, Nucleus, Peripheral membrane protein, coated pit
Calculated MW:66kDa/83kDa/94kDa/99kDa
Observed MW:110kDa
Synonyms:EPS15L1, EPS15R
Background:
UniProt Protein Function:EPS15R: epidermal growth factor receptor substrate protein 15R. Contains three EH domains which are implicated in endocytosis, vesicle transport and signal transduction. All three EH domains contain calcium-binding domains ofthe EF-hand type. Contains 2 UIM motifs, which are is responsible for ubiquitin recognition and monoubiquitination. May function as an adaptor between ubiquitinated proteins and the clathrin coat or other endocytic scaffolds.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: membrane; plasma membrane; coated pit; nucleus

Molecular Function:protein binding; calcium ion binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; endocytosis

UniProt Code:Q9UBC2
NCBI GenInfo Identifier:385428859
NCBI Gene ID:58513
NCBI Accession:NP_001245303.1
UniProt Related Accession:Q9UBC2
Molecular Weight:
NCBI Full Name:epidermal growth factor receptor substrate 15-like 1 isoform 1
NCBI Synonym Full Names:epidermal growth factor receptor pathway substrate 15 like 1
NCBI Official Symbol:EPS15L1  
NCBI Official Synonym Symbols:EPS15R  
NCBI Protein Information:epidermal growth factor receptor substrate 15-like 1
UniProt Protein Name:Epidermal growth factor receptor substrate 15-like 1
UniProt Synonym Protein Names:Eps15-related protein
UniProt Gene Name:EPS15L1  
UniProt Entry Name:EP15R_HUMAN
Anti-EPS15L1 Antibody (CAB7828)Western blot analysis of extracts of various cell lines, using EPS15L1 antibody (CAB7828) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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