Immunology Antibodies 2
Anti-EPO Antibody (CAB5663)
- SKU:
- CAB5663
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-EPO Antibody |
| Antibody SKU: | CAB5663 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human EPO |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, Mouse liver, Rat liver, Rat kidney |
| Immunogen: | A synthetic peptide of human EPO |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2056 |
| Uniprot: | P01588 |
| Cellular Location: | Secreted |
| Calculated MW: | 21kDa |
| Observed MW: | 30kDa |
| Synonyms: | EPO, EP, MVCD2 |
| Background: | This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. |
| UniProt Protein Function: | EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: cell surface; extracellular region; extracellular space Molecular Function:erythropoietin receptor binding; protein binding Biological Process: cell proliferation; erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2 |
| NCBI Summary: | This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P01588 |
| NCBI GenInfo Identifier: | 119526 |
| NCBI Gene ID: | 2056 |
| NCBI Accession: | P01588.1 |
| UniProt Secondary Accession: | P01588,Q2M2L6, Q549U2, Q9UDZ0, Q9UEZ5, Q9UHA0, |
| UniProt Related Accession: | P01588 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | Erythropoietin |
| NCBI Synonym Full Names: | erythropoietin |
| NCBI Official Symbol: | EPO |
| NCBI Official Synonym Symbols: | EP; MVCD2 |
| NCBI Protein Information: | erythropoietin |
| UniProt Protein Name: | Erythropoietin |
| UniProt Synonym Protein Names: | INN: Epoetin |
| Protein Family: | Erythropoietin |
| UniProt Gene Name: | EPO |
 | Western blot analysis of extracts of various cell lines, using EPO antibody (CAB5663) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human esophagus using EPO antibody (CAB5663) (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat liver using EPO antibody (CAB5663) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using EPO antibody (CAB5663) (40x lens). |
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