Metabolism Antibodies 2
Anti-EPHX2 Antibody (CAB1885)
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- SKU:
- CAB1885
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-EPHX2 Antibody |
| Antibody SKU: | CAB1885 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human EPHX2 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, LO2, SW480, Mouse liver, Mouse kidney, Mouse heart, Rat kidney |
| Immunogen: | Recombinant protein of human EPHX2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2053 |
| Uniprot: | P34913 |
| Cellular Location: | Cytoplasm, Peroxisome |
| Calculated MW: | 55kDa/57kDa/62kDa |
| Observed MW: | 63kDa |
| Synonyms: | EPHX2, CEH, SEH |
| Background: | This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | EPHX2: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - arachidonic acid; EC 3.1.3.76; EC 3.3.2.10; Hydrolase Chromosomal Location of Human Ortholog: 8p21 Cellular Component: cytoplasm; peroxisome; cytosol Molecular Function:toxin binding; protein homodimerization activity; lipid-phosphate phosphatase activity; epoxide hydrolase activity; phosphoric monoester hydrolase activity; magnesium ion binding; lipid phosphatase activity; receptor binding Biological Process: response to toxin; epoxygenase P450 pathway; stilbene catabolic process; positive regulation of vasodilation; phospholipid dephosphorylation; cellular calcium ion homeostasis; cholesterol homeostasis; dephosphorylation; regulation of blood pressure; xenobiotic metabolic process; arachidonic acid metabolic process; drug metabolic process; inflammatory response Disease: Hypercholesterolemia, Familial |
| NCBI Summary: | This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P34913 |
| NCBI GenInfo Identifier: | 67476665 |
| NCBI Gene ID: | 2053 |
| NCBI Accession: | P34913.2 |
| UniProt Secondary Accession: | P34913,Q16764, Q9HBJ1, Q9HBJ2, B2Z3B1, B3KTU8, B3KUA0 G3V134, J3KPH7, |
| UniProt Related Accession: | P34913 |
| Molecular Weight: | 555 |
| NCBI Full Name: | Bifunctional epoxide hydrolase 2 |
| NCBI Synonym Full Names: | epoxide hydrolase 2, cytoplasmic |
| NCBI Official Symbol: | EPHX2 |
| NCBI Official Synonym Symbols: | CEH; SEH |
| NCBI Protein Information: | bifunctional epoxide hydrolase 2; epoxide hydratase; epoxide hydrolase, soluble; epoxide hydrolase 2, cytosolic |
| UniProt Protein Name: | Bifunctional epoxide hydrolase 2 |
| UniProt Synonym Protein Names: | Epoxide hydratase; Soluble epoxide hydrolase; SEH |
| UniProt Gene Name: | EPHX2 |
| UniProt Entry Name: | HYES_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EPHX2 antibody (CAB1885) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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