Metabolism Antibodies 2
Anti-EPHX1 Antibody (CAB2070)
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- SKU:
- CAB2070
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-EPHX1 Antibody |
| Antibody SKU: | CAB2070 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human EPHX1 (NP_000111.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, K-562, Mouse liver, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human EPHX1 (NP_000111.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SRDK EETL PLED GWWG PGTR SAAR EDDS IRPF KVET SDEE IHDL HQRI DKFR FTPP LEDS CFHY GFNS NYLK KVIS YWRN EFDW KKQV EILN RYPH FKTK IEGL DIHF IHVK PPQL PAGH TPKP LLMV HGWP GSFY EFYK IIPL LTDP KNHG LSDE HVFE VICP SIPG YGFS EASS KKGF NSVA TARI FYKL MLRL GFQE FYIQ GGDW GSLI CTNM AQLV PSHV KGLH LNMA LVLS NFST LTLL LGQR FGRF LGLT ERDV ELLY PVKE KVFY SLMR ESGY MHIQ CTKP DTVG SALN DSPV G |
| Gene ID: | 2052 |
| Uniprot: | P07099 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Single-pass type II membrane protein |
| Calculated MW: | 52kDa |
| Observed MW: | 48kDa |
| Synonyms: | EPHX1, EPHX, EPOX, HYL1, MEH |
| Background: | Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | Ephx1: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. Defects in EPHX1 are a cause of familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the peptidase S33 family. |
| UniProt Protein Details: | Protein type:EC 3.3.2.9; Xenobiotic Metabolism - metabolism by cytochrome P450; Membrane protein, integral; Hydrolase Chromosomal Location of Human Ortholog: 1q42.1 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity Biological Process: response to toxin; response to organic cyclic substance; aromatic compound catabolic process Disease: Hypercholanemia, Familial; Preeclampsia/eclampsia 1 |
| NCBI Summary: | Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008] |
| UniProt Code: | P07099 |
| NCBI GenInfo Identifier: | 123926 |
| NCBI Gene ID: | 2052 |
| NCBI Accession: | P07099.1 |
| UniProt Secondary Accession: | P07099,Q5VTJ6, Q9NP75, Q9NPE7, Q9NQU6, Q9NQU7, Q9NQU8 Q9NQU9, Q9NQV0, Q9NQV1, Q9NQV2, B2R8N0, |
| UniProt Related Accession: | P07099 |
| Molecular Weight: | 455 |
| NCBI Full Name: | Epoxide hydrolase 1 |
| NCBI Synonym Full Names: | epoxide hydrolase 1, microsomal (xenobiotic) |
| NCBI Official Symbol: | EPHX1 |
| NCBI Official Synonym Symbols: | MEH; EPHX; EPOX; HYL1 |
| NCBI Protein Information: | epoxide hydrolase 1; epoxide hydratase |
| UniProt Protein Name: | Epoxide hydrolase 1 |
| UniProt Synonym Protein Names: | Epoxide hydratase; Microsomal epoxide hydrolase |
| UniProt Gene Name: | EPHX1 |
| UniProt Entry Name: | HYEP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using EPHX1 antibody (CAB2070) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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