Cardiovascular Antibodies
Anti-Ephrin B2 Antibody (CAB11349)
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- SKU:
- CAB11349
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-Ephrin B2 Antibody |
| Antibody SKU: | CAB11349 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Ephrin B2 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, A-549, MCF7, Mouse lung, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human Ephrin B2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1948 |
| Uniprot: | P52799 |
| Cellular Location: | |
| Calculated MW: | 50kDa |
| Observed MW: | 55KDa |
 | Western blot - Ephrin B2 Rabbit mAb (CAB11349) |
| Synonyms: | EPLG5, HTKL, Htk-L, LERK5 |
| Background: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | EFNB2: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Membrane protein, integral Chromosomal Location of Human Ortholog: 13q33 Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane Molecular Function:protein binding; ephrin receptor binding Biological Process: axon guidance; organ morphogenesis; anatomical structure morphogenesis; regulation of chemotaxis; viral reproduction; cell-cell signaling; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; cell adhesion; lymph vessel development |
| NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52799 |
| NCBI GenInfo Identifier: | 1706673 |
| NCBI Gene ID: | 1948 |
| NCBI Accession: | P52799.1 |
| UniProt Secondary Accession: | P52799,Q5JV56, |
| UniProt Related Accession: | P52799 |
| Molecular Weight: | 333 |
| NCBI Full Name: | Ephrin-B2 |
| NCBI Synonym Full Names: | ephrin-B2 |
| NCBI Official Symbol: | EFNB2 |
| NCBI Official Synonym Symbols: | HTKL; EPLG5; Htk-L; LERK5 |
| NCBI Protein Information: | ephrin-B2; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5 |
| UniProt Protein Name: | Ephrin-B2 |
| UniProt Synonym Protein Names: | EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNB2 |
| UniProt Entry Name: | EFNB2_HUMAN |
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