Cell Death Antibodies 2
Anti-EPHA7 Antibody (CAB9931)
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- SKU:
- CAB9931
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-EPHA7 Antibody |
| Antibody SKU: | CAB9931 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-190 of human EPHA7 (NP_004431.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, A-549, Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-190 of human EPHA7 (NP_004431.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QAAK EVLL LDSK AQQT ELEW ISSP PNGW EEIS GLDE NYTP IRTY QVCQ VMEP NQNN WLRT NWIS KGNA QRIF VELK FTLR DCNS LPGV LGTC KETF NLYY YETD YDTG RNIR ENLY VKID TIAA DESF TQGD LGER KMKL NTEV REIG PLSK KGFY LAFQ DVG |
| Gene ID: | 2045 |
| Uniprot: | Q15375 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 31kDa/50kDa/111kDa/112kDa |
| Observed MW: | 112kDa |
| Synonyms: | EPHA7, EHK-3, EHK3, EK11, HEK11 |
| Background: | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | EphA7: a widely-expressed receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5. Contains 1 sterile alpha motif (SAM) and two fibronectin type III domains. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Eph family Chromosomal Location of Human Ortholog: 6q16.1 Cellular Component: plasma membrane Molecular Function:axon guidance receptor activity; chemorepellent activity; GPI-linked ephrin receptor activity; protein binding; protein-tyrosine kinase activity Biological Process: brain development; branching morphogenesis of a nerve; ephrin receptor signaling pathway; negative chemotaxis; phosphorylation; positive regulation of neuron apoptosis; regulation of caspase activity; regulation of cell-cell adhesion; regulation of peptidyl-tyrosine phosphorylation; regulation of protein amino acid autophosphorylation |
| NCBI Summary: | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | Q15375 |
| NCBI GenInfo Identifier: | 146345416 |
| NCBI Gene ID: | 2045 |
| NCBI Accession: | Q15375.3 |
| UniProt Secondary Accession: | Q15375,Q59G40, Q5VTU0, Q8N368, Q9H124, A0AUX7, B2R8W1 B7ZLJ9, B7ZLK0, |
| UniProt Related Accession: | Q15375 |
| Molecular Weight: | 50,521 Da |
| NCBI Full Name: | Ephrin type-A receptor 7 |
| NCBI Synonym Full Names: | EPH receptor A7 |
| NCBI Official Symbol: | EPHA7 |
| NCBI Official Synonym Symbols: | EHK3; EK11; EHK-3; HEK11 |
| NCBI Protein Information: | ephrin type-A receptor 7 |
| UniProt Protein Name: | Ephrin type-A receptor 7 |
| UniProt Synonym Protein Names: | EPH homology kinase 3; EHK-3; EPH-like kinase 11; EK11; hEK11 |
| Protein Family: | Ephrin type-A receptor |
| UniProt Gene Name: | EPHA7 |
| UniProt Entry Name: | EPHA7_HUMAN |
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